Hsa-circVIM regulates breast cancer tumor progression and tamoxifen sensitivity by sponging miR-1294 in hormone receptor-positive breast cancer cells
Elevated hsa-circVIM expression in breast cancer suggested its potential as a prognostic biomarker. hsa-circVIM functions as both a cancer-promoting molecule and a regulator of TAM responsiveness in HR-positive breast cancer cells by regulating miR-1294 expression. Therefore, hsa-circVIM serves as a potent biomarker for prognosis, plays a promoting role in breast cancer progression, and may offer a therapeutic avenue to overcome TAM resistance.
Authors
- Peng Dai
- Xiaoyan Zhu (ORCID: https://orcid.org/0000-0001-6967-8942)
- Zhenhua Zhang (ORCID: https://orcid.org/0000-0002-8480-9004)
- Ying Chen (ORCID: https://orcid.org/0000-0001-5148-6504)
- Xue Luo (ORCID: https://orcid.org/0000-0003-0479-228X)
- M. Cen
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Affiliated Hospital of Youjiang Medical University for Nationalities (CN)
- Baise University (CN)
- Xiamen Chang Gung Hospital (CN)
- Shandong Maternal and Child Health Hospital (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1007/s12672-025-02485-4
- Citations
- 1
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.81