LSD1 induces H3 K9 demethylation to promote adipogenesis in thyroid-associated ophthalmopathy
Overall, our study indicates that epigenetic modifications were dysregulated in TAO process, and these data elucidated a novel mechanism of adipocyte differentiation during TAO progression and positioned LSD1 as a potential anti-adipogenesis target in TAO. Further understanding of the interaction betwen transcription factors and epigeneic modifiers or other histone modifications in TAO is essential for providing new perspectives in TAO mechanistic study and clinical intervention.
Authors
- Yuhang Fan (ORCID: https://orcid.org/0009-0005-8230-6410)
- Licheng Sun (ORCID: https://orcid.org/0000-0002-4521-2870)
- Jin Zhang (ORCID: https://orcid.org/0000-0003-0197-3624)
- Yuyan Xu
- Ning Shen (ORCID: https://orcid.org/0000-0003-0628-3497)
- Hui Chen (ORCID: https://orcid.org/0000-0002-1633-6348)
- Fang Zhang (ORCID: https://orcid.org/0000-0002-7000-554X)
- Ling Zhang (ORCID: https://orcid.org/0000-0002-7917-7671)
- Jing Hu (ORCID: https://orcid.org/0000-0001-9290-2850)
- Qihuang Jin (ORCID: https://orcid.org/0000-0002-7319-1157)
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai First People's Hospital (CN)
- First Affiliated Hospital Zhejiang University (CN)
Publication Details
- Journal
- Epigenetics & Chromatin
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1186/s13072-025-00586-6
- Citations
- 1
- Primary Topic
- Thyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.29
Funders
- National Science Foundation
- Fundamental Research Funds for the Central Universities
- Science and Technology Department of Zhejiang Province