Physiological comparison of noninvasive ventilation and high-flow nasal oxygen on inspiratory efforts and tidal volumes after extubation: a randomized crossover trial
In patients at high-risk of extubation failure, prophylactic NIV significantly decreased inspiratory efforts with increased tidal volumes compared to HFNO. The clinical benefits of NIV to prevent reintubation in patients at high-risk may be mediated by these physiological effects. Trial registration Clinicaltrials.gov: ID NCT04036175), retrospectively registered 17 June 2019.
Authors
- Alejandro Bruhn (ORCID: https://orcid.org/0000-0001-8034-1937)
- Sylvain Le Pape (ORCID: https://orcid.org/0000-0001-7439-7184)
- Rémi Coudroy (ORCID: https://orcid.org/0000-0002-0036-1899)
- Erik Etien (ORCID: https://orcid.org/0000-0003-1996-2755)
- C. Beuvon
- Adrien Lehalleur
- Samuel Tuffet (ORCID: https://orcid.org/0000-0002-1112-9163)
- François Arrivé (ORCID: https://orcid.org/0009-0006-7158-050X)
- Arnaud Wilfrid Thille (ORCID: https://orcid.org/0000-0002-7798-6715)
- Jean-Pierre Frat
- Laurent Rambault
Institutions
- Inserm (FR)
- Pontificia Universidad Católica de Chile (CL)
- Université de Poitiers (FR)
- Centre Hospitalier Universitaire de Poitiers (FR)
- Centre Hospitalier Saint-Joseph Saint-Luc (FR)
Publication Details
- Journal
- Critical Care
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1186/s13054-025-05366-y
- Citations
- 6
- Primary Topic
- Respiratory Support and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 9.11