Antibiotic Loaded Bone Cement in Primary Total Hip and Knee Arthroplasty
Background Antibiotic loaded bone cement (ALBC) is currently approved by the United States Food and Drug Administration for use in revision arthroplasty for periprosthetic joint infection, but not primary arthroplasty. Still, ALBC is commonly used prophylactically in primary arthroplasty. Methods Committee statements, registry data, and clinical and basic science research on ALBC in primary hip and knee arthroplasty were reviewed. Conclusion High-level evidence is limited at the current time. Clinical trials enrolling patients at highest risk for PJI are warranted to provide guidance for appropriate use of ALBC in the primary setting.
Authors
- H. John Cooper (ORCID: https://orcid.org/0000-0002-9272-668X)
- Zachary P. Berliner (ORCID: https://orcid.org/0000-0002-4523-3241)
- David M. Freccero (ORCID: https://orcid.org/0000-0002-2444-7099)
- Eric L. Smith (ORCID: https://orcid.org/0000-0003-1609-7639)
- Michaël Kain (ORCID: https://orcid.org/0000-0002-6413-4775)
Institutions
- Boston Medical Center (US)
- Albert Einstein College of Medicine (US)
- New England Baptist Hospital (US)
- Montefiore Medical Center (US)
- Columbia University Irving Medical Center (US)
Publication Details
- Journal
- Montefiore Einstein Journal of Musculoskeletal Medicine and Surgery
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1177/30498929251329316
- Citations
- 1
- Primary Topic
- Orthopedic Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.01