Characterization of Serotype-Specific Dengue Virus T-Cell Inhibition
DENV-2 and -3 are associated with more severe clinical disease than DENV-1 and -4; however, no biological explanation for this difference has been previously identified. We found that DENV-1 and -4 viral particles and env proteins blunt T-cell responses by interfering with proximal TCR signaling, while DENV-2 and -3 do not, potentially explaining DENV pathogenic outcomes in primary and secondary infection.
Authors
- Qing Chang (ORCID: https://orcid.org/0000-0001-5138-8760)
- Jon C. D. Houtman (ORCID: https://orcid.org/0000-0002-5307-9854)
- Jack T. Stapleton (ORCID: https://orcid.org/0000-0002-2302-9055)
- Hillel Haim (ORCID: https://orcid.org/0000-0002-6071-5089)
- Micaela G. Fosdick (ORCID: https://orcid.org/0000-0002-2427-532X)
- Tomokazu Tamura (ORCID: https://orcid.org/0000-0003-1395-6610)
- Wesley J. Hottel
- Nirjal Bhattarai (ORCID: https://orcid.org/0000-0003-1798-8863)
- James H. McLinden
- Alexander Ploß (ORCID: https://orcid.org/0000-0001-9322-7252)
- Jiayu Zhang (ORCID: https://orcid.org/0000-0001-7228-8320)
- Jinhua Xiang (ORCID: https://orcid.org/0000-0002-8512-8278)
Institutions
- University of Iowa (US)
- Center for Biologics Evaluation and Research (US)
- United States Food and Drug Administration (US)
- Iowa State University (US)
- Princeton University (US)
- Iowa City VA Health Care System (US)
- Iowa City VA Medical Center (US)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1093/infdis/jiaf241
- Citations
- 1
- Primary Topic
- Mosquito-borne diseases and control
- Type
- article
- Field-Weighted Citation Impact
- 1.88