Mutating the cysteine residues within the <scp>WCCH</scp> motif of tobacco curly shoot virus (<scp>TbCSV</scp>) <scp>V2</scp> protein attenuates viral infection and confers cross‐protection against infection by severe strain
The cysteine residues within the 'WCCH' motif of TbCSV V2 protein play distinct roles in its functions and viral pathogenicity. Importantly, the attenuated C84A mutant generated in this study not only offers insights into the pathogenic mechanisms of TbCSV but also holds promise for application in crop protection through cross-protection strategy in the field. © 2025 Society of Chemical Industry.
Authors
- W. H. Tian (ORCID: https://orcid.org/0009-0000-0299-9047)
- Gentu Wu (ORCID: https://orcid.org/0000-0002-4256-2808)
- Jiayao Liu
- Zeyi Xiao (ORCID: https://orcid.org/0000-0001-9086-8003)
- Ling Qing (ORCID: https://orcid.org/0000-0002-1188-9138)
- Jane C. Deng (ORCID: https://orcid.org/0000-0002-0476-1283)
- Shengyu Jiang
- Yuan Yuan (ORCID: https://orcid.org/0000-0002-7309-5392)
- Yang Yang (ORCID: https://orcid.org/0000-0003-3973-2738)
- Li Qiao
- Mingjun Li (ORCID: https://orcid.org/0000-0003-0278-9810)
Institutions
- Southwest University (CN)
Publication Details
- Journal
- Pest Management Science
- Published
- 2025-05-07
- DOI
- https://doi.org/10.1002/ps.8869
- Citations
- 1
- Primary Topic
- Plant Virus Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.75
Funders
- Natural Science Foundation of Chongqing
- Fundamental Research Funds for the Central Universities