Case Series on Varied Presentations of Amlodipine Toxicity

Calcium channel blockers (CCBs) are among the most widely prescribed drugs for cardiovascular illnesses. Angina pectoris, cardiac arrhythmias, hypertension, and other conditions are treated with calcium channel blockers (CCBs). Both immediate-release and extended-release versions of these drugs are available; the latter are often used in therapeutic settings. While extended-release CCB overdoses can cause delayed start of dysrhythmias, shock, sudden cardiac collapse, and intestinal ischemia, immediate-release CCB overdoses are characterized by rapid progression to hypotension, bradydysrhythmia, and cardiac arrest. The present case series consists of five cases of amlodipine toxicity that were treated at Rajiv Gandhi General Government Hospital and had a range of clinical manifestations. The present case series also includes two cases of non-cardiogenic pulmonary edema, a rare presentation of amlodipine poisoning.

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Journal
Cureus
Published
2025-05-07
DOI
https://doi.org/10.7759/cureus.83697
Primary Topic
Poisoning and overdose treatments
Type
article
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article

Case Series on Varied Presentations of Amlodipine Toxicity

Kadarkarai Murugan, S Yogesh, Sandhiya Narendiran, Chandrasekhara Hariharan et al.
Cureus
Poisoning and overdose treatments
article

Case Series on Varied Presentations of Amlodipine Toxicity

Kadarkarai Murugan, S Yogesh, Sandhiya Narendiran, Chandrasekhara Hariharan, Srinivas Sridhar, A. Marimuthu, Sahasyaa Adalarasan, S Shivamalarvizhi
article en

Abstract

Calcium channel blockers (CCBs) are among the most widely prescribed drugs for cardiovascular illnesses. Angina pectoris, cardiac arrhythmias, hypertension, and other conditions are treated with calcium channel blockers (CCBs). Both immediate-release and extended-release versions of these drugs are available; the latter are often used in therapeutic settings. While extended-release CCB overdoses can cause delayed start of dysrhythmias, shock, sudden cardiac collapse, and intestinal ischemia, immediate-release CCB overdoses are characterized by rapid progression to hypotension, bradydysrhythmia, and cardiac arrest. The present case series consists of five cases of amlodipine toxicity that were treated at Rajiv Gandhi General Government Hospital and had a range of clinical manifestations. The present case series also includes two cases of non-cardiogenic pulmonary edema, a rare presentation of amlodipine poisoning.

CureusVol. 17(5)
Madras Medical College (IN), Government General Hospital (IN)
Zero hunger
Openalex Percentile: Top 84%
Poisoning and overdose treatments
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Case Series on Varied Presentations of Amlodipine Toxicity — Kadarkarai Murugan, S Yogesh, et al. · Cureus (2025) | TGRS Research Map | TGRS