Plasma biomarkers as core mediators in functional network abnormalities: Evidence from a two‐cohort study
Plasma biomarkers demonstrated significant mediating effects on Aβ deposition and functional network alterations across different Aβ stages in both East Asian and Western cohorts. Significant functional connectivity variations in different brain networks were observed throughout AD progression in two cohorts, particularly across various Aβ stages. Among all plasma biomarkers, p-tau217 and p-tau181 demonstrated more comprehensive and fully mediating effects compared to other biomarkers, influencing connectivity alterations in the various functional networks. The plasma biomarkers exhibited great potential for tracking pathologic progression, functional network alterations, and early disease identification in East Asian and Western cohorts.
Authors
- Jiehui Jiang
- Fulu Tao (ORCID: https://orcid.org/0000-0001-8574-0080)
- Min Wei
- Wenjing Hu (ORCID: https://orcid.org/0000-0003-4375-1341)
- Wenhui Chai
- Shuyu Zhang (ORCID: https://orcid.org/0000-0003-0579-3444)
- Chenyang Li (ORCID: https://orcid.org/0000-0002-4406-9224)
- Rong Shi (ORCID: https://orcid.org/0000-0002-6440-1263)
- Ying Zhang (ORCID: https://orcid.org/0000-0002-6556-3301)
- Xianfeng Yu (ORCID: https://orcid.org/0000-0001-7293-8776)
- Min Wang (ORCID: https://orcid.org/0000-0002-3436-4246)
- Luyao Wang (ORCID: https://orcid.org/0000-0002-9488-4040)
- Jiayi Zhong (ORCID: https://orcid.org/0009-0008-7372-0697)
- Ziyan Song (ORCID: https://orcid.org/0009-0002-7039-4116)
- Guanqun Chen (ORCID: https://orcid.org/0000-0002-8133-834X)
- Ying Han (ORCID: https://orcid.org/0000-0002-6474-8283)
- Qi Zhang (ORCID: https://orcid.org/0000-0002-7936-8726)
Institutions
- Shanghai University (CN)
- Capital Medical University (CN)
- Anhui Medical University (CN)
- Hainan University (CN)
- Beijing Chao-Yang Hospital, Capital Medical University (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Shenzhen Bay Laboratory (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Karamay Central Hospital of Xinjiang (CN)
- State Key Laboratory of Digital Medical Engineering (CN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/alz.70114
- Citations
- 2
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.86
Funders
- Alzheimer's Disease Neuroimaging Initiative
- National Natural Science Foundation of China