Resveratrol improved atherosclerosis by increasing LDLR levels via the EGFR-ERK1/2 signaling pathway
This study elucidated the mechanism by which RSV upregulates LDLR gene expression through activating EGFR-ERK1/2 signaling pathway. In vivo experiments demonstrated its efficacy in reducing arterial plaque formation and stabilizing existing plaques. These results further indicated that RSV held potential therapeutic value for ameliorating atherosclerosis and cardiovascular diseases. Collectively, these findings provided novel theoretical support for RSV's potential role in cardiovascular therapy.
Authors
- Dandan Hu (ORCID: https://orcid.org/0000-0001-7905-8536)
- Lin Qi
- Xuanjun Wang (ORCID: https://orcid.org/0000-0003-1211-506X)
- Jun Sheng (ORCID: https://orcid.org/0000-0002-8433-1864)
- Heng Yin (ORCID: https://orcid.org/0000-0002-8942-7742)
- Yuebo Jin (ORCID: https://orcid.org/0000-0003-3379-8998)
- Litian Wang (ORCID: https://orcid.org/0000-0002-1618-1008)
- Yewei Huang (ORCID: https://orcid.org/0000-0002-8805-9351)
- Xiangxuan Yang
Institutions
- Yunnan Agricultural University (CN)
- Kunming Medical University (CN)
Publication Details
- Journal
- Lipids in Health and Disease
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1186/s12944-025-02585-8
- Citations
- 3
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 3.67