Smoking as a risk factor for rheumatoid arthritis: predominant association with IgA autoantibodies – comprehensive analysis of anti-modified protein antibodies with smoking and genetic risk factors in rheumatoid arthritis
These data provide a pivotal refinement of existing knowledge regarding risk factor associations for RA and lend novel support to the hypothesis that smoking may exert its effect on RA by the induction of local (auto)immune responses at mucosal sites.
Authors
- Judith W Heutz (ORCID: https://orcid.org/0000-0002-2126-7922)
- Annemarie L Dorjée
- Diane van der Woude (ORCID: https://orcid.org/0000-0001-8121-5879)
- Rachel Knevel (ORCID: https://orcid.org/0000-0002-7494-3023)
- Pascal H P de Jong (ORCID: https://orcid.org/0000-0001-6628-6222)
- Anna Svärd (ORCID: https://orcid.org/0000-0002-2470-4307)
- René E. M. Toes (ORCID: https://orcid.org/0000-0002-9618-6414)
- T. Huizinga (ORCID: https://orcid.org/0000-0001-7033-7520)
- M. Maurits (ORCID: https://orcid.org/0000-0002-3266-6232)
- Fraser Morton (ORCID: https://orcid.org/0000-0001-5328-9467)
- Duncan Porter (ORCID: https://orcid.org/0000-0001-8481-5204)
- Karim Raza (ORCID: https://orcid.org/0000-0003-1570-1232)
- Tineke J van Wesemael (ORCID: https://orcid.org/0000-0002-3101-0530)
Institutions
- Uppsala University (SE)
- Leiden University Medical Center (NL)
- Bronglais General Hospital (GB)
- Erasmus MC (NL)
- Hywel Dda University Health Board (GB)
- Center for Clinical Research Dalarna (SE)
- NIHR Birmingham Biomedical Research Centre (GB)
- University of Glasgow (GB)
- University of Birmingham (GB)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1186/s13075-025-03543-6
- Citations
- 7
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 9.52
Funders
- European Commission