Investigation of Fructus sophorae extract’s therapeutic mechanism in atrophic vaginitis based on network pharmacology and experimental validation
FS demonstrates multi-target regulatory capacity, specifically modulating p-PI3K/PI3K, p-AKT/AKT, ERα, EGF, and EGFR signaling pathways, which substantiates its potential as a promising therapeutic agent for AV. These findings provide mechanistic insights into FS's therapeutic targets against AV, establishing a theoretical foundation for its translational application in AV therapy.
Authors
- Guangrui Wang (ORCID: https://orcid.org/0000-0002-6033-5270)
- Jiarui Zheng (ORCID: https://orcid.org/0000-0002-1854-9558)
- Mingjiang Yao (ORCID: https://orcid.org/0000-0001-7165-9484)
- Xiaodi Fan (ORCID: https://orcid.org/0000-0002-5004-7099)
- Weiming Wang (ORCID: https://orcid.org/0000-0002-9068-0227)
- Lin Li (ORCID: https://orcid.org/0000-0002-3338-0869)
- Feng Li (ORCID: https://orcid.org/0000-0002-7961-3728)
- Wenting Song (ORCID: https://orcid.org/0009-0004-5077-6330)
- Jianxun Liu (ORCID: https://orcid.org/0000-0001-6870-7094)
- Junguo Ren
- Zishan Huang (ORCID: https://orcid.org/0009-0006-6046-9291)
- YeHao Zhang
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Xiyuan Hospital (CN)
- China Academy of Chinese Medical Sciences (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-05-08
- DOI
- https://doi.org/10.3389/fphar.2025.1571976
- Citations
- 2
- Primary Topic
- Medicinal plant effects and applications
- Type
- article
- Field-Weighted Citation Impact
- 4.76
Funders
- Science and Technology Department, Heilongjiang Province