Decoding multiple myeloma: single-cell insights into tumor heterogeneity, immune dynamics, and disease progression

This single-cell analysis provided new insights into the cellular diversity and differentiation trajectories in MM, offering a deeper understanding of the complex neuroimmune interactions that drive tumor progression and resistance. By incorporating the role of neuroinflammation and immune modulation, our study suggested novel therapeutic strategies targeting the neuroimmune axis in oncology, ultimately contributing to the development of more effective, personalized treatment approaches for MM.

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Publication Details

Journal
Frontiers in Immunology
Published
2025-05-08
DOI
https://doi.org/10.3389/fimmu.2025.1584350
Citations
18
Primary Topic
Multiple Myeloma Research and Treatments
Type
article
Field-Weighted Citation Impact
31.86
Controls
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article

Decoding multiple myeloma: single-cell insights into tumor heterogeneity, immune dynamics, and disease progression

Yujiang Dong, Zhikai Xiahou, Zhiheng Lin, Bao Weiying et al.
18 citations
Frontiers in Immunology
Multiple Myeloma Research and Treatments
31.86
article

Decoding multiple myeloma: single-cell insights into tumor heterogeneity, immune dynamics, and disease progression

Yujiang Dong, Zhikai Xiahou, Zhiheng Lin, Bao Weiying, Lu Fan, Zhijie Zhao, Zhenzhen Zhao
article en
18 citations

Abstract

This single-cell analysis provided new insights into the cellular diversity and differentiation trajectories in MM, offering a deeper understanding of the complex neuroimmune interactions that drive tumor progression and resistance. By incorporating the role of neuroinflammation and immune modulation, our study suggested novel therapeutic strategies targeting the neuroimmune axis in oncology, ultimately contributing to the development of more effective, personalized treatment approaches for MM.

Frontiers in ImmunologyVol. 16
Shandong University of Traditional Chinese Medicine (CN), Shanghai Jiao Tong University (CN), Shanghai Ninth People's Hospital (CN), Shanghai University of Traditional Chinese Medicine (CN), Longhua Hospital Shanghai University of Traditional Chinese Medicine (CN), Second Hospital of Shandong University (CN), Tongren Hospital (CN), Songjiang District Central Hospital (CN), Beijing Sport University (CN)
Openalex Percentile: Top 0%
Multiple Myeloma Research and Treatments
31.86
DOIOpen Access PDFOpenAlex
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