Rat embryonic stem cell-based in vitro testing platform for mammalian embryo toxicology at pre- and post-implantation stages
The RESCs-based platform allowed reproducible, robust and highly predictable results, thanks to the coupling of RESCs with high-throughput technologies. These results support the possible use of RESCs-based models as a screening platform for developmental toxicity testing to reduce the number of animals currently used for this aim.
Authors
- Laura Calzà (ORCID: https://orcid.org/0000-0002-4426-8477)
- Vito Antonio Baldassarro (ORCID: https://orcid.org/0000-0003-1020-4261)
- Corinne Quadalti (ORCID: https://orcid.org/0000-0002-0302-3027)
- Luciana Giardino (ORCID: https://orcid.org/0000-0003-3107-3264)
- Marzia Moretti
- Fulvia Ferrazzi (ORCID: https://orcid.org/0000-0003-4011-4638)
Institutions
- Fondazione IRET ONLUS (IT)
- University of Bologna (IT)
Publication Details
- Journal
- Frontiers in Toxicology
- Published
- 2025-05-08
- DOI
- https://doi.org/10.3389/ftox.2025.1561386
- Primary Topic
- Pluripotent Stem Cells Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00