Optimal fractionation scheme for lymphocyte infiltration in glioblastoma multiforme radiotherapy
Using RT as an immune primer in GBM would require very high and toxic doses with conventional RT methods. While 25 Gy is used in conventional stereotactic radiosurgery, such a high dose is typically limited to small brain volumes. Novel approaches, such as FLASH-RT or minibeam RT, offer alternatives to mitigate toxicity while achieving the required doses.
Authors
- Yolanda Prezado (ORCID: https://orcid.org/0000-0001-5957-2327)
- Julie Espenon (ORCID: https://orcid.org/0009-0004-7142-9194)
- Marjorie Juchaux (ORCID: https://orcid.org/0009-0003-3662-0674)
- Lorea Iturri (ORCID: https://orcid.org/0000-0002-7911-3117)
- Cristèle Gilbert (ORCID: https://orcid.org/0009-0008-5018-860X)
- Annaïg Bertho (ORCID: https://orcid.org/0009-0002-4526-0861)
- Sarah Potiron (ORCID: https://orcid.org/0009-0002-1187-9535)
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Universidade de Santiago de Compostela (ES)
- Université Paris Sciences et Lettres (FR)
- Université Paris-Saclay (FR)
- Xunta de Galicia (ES)
- Center for Research in Molecular Medicine and Chronic Diseases (ES)
- Instituto de Investigación Sanitaria de Santiago (ES)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-05-08
- DOI
- https://doi.org/10.3389/fonc.2025.1493436
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Agence Nationale de la Recherche