Microbiota profiling from biopsied tissues in complex infections: a diagnostic and prognostic analysis through metagenomic next-generation sequencing
mNGS demonstrates significant diagnostic and prognostic efficacy in patients undergoing tissue biopsy for suspected complex infections. The presence of Gram-negative bacteria, Enterobacteriaceae, and Staphylococcus is associated with a higher probability of treatment failure, which underscores the advantage of using mNGS to guide more aggressive antibiotic strategies.
Authors
- Tiange Song
- Dandan Tie
- Jie Zhang (ORCID: https://orcid.org/0000-0003-1587-503X)
- Li Jiang (ORCID: https://orcid.org/0000-0002-8530-4737)
- Xiaoyan Tao
- Xiaoli Zhou (ORCID: https://orcid.org/0000-0002-8454-9417)
- Lin Yin (ORCID: https://orcid.org/0000-0003-3604-506X)
Institutions
- University of Electronic Science and Technology of China (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-05-08
- DOI
- https://doi.org/10.3389/fcimb.2025.1567981
- Citations
- 2
- Primary Topic
- Infectious Diseases and Tuberculosis
- Type
- article
- Field-Weighted Citation Impact
- 4.01
Funders
- National Natural Science Foundation of China