Single cell RNA-sequencing identified CCR7+/RELB+/IRF1+ T cell responding for juvenile idiopathic arthritis pathogenesis
Our study provided evidence of cellular and molecular levels of involvement in JIA pathogenesis and identified the critical roles for T cells in JIA pathogenesis. Furthermore, our results suggested that there were significant differences in T cell composition and gene expression between HLA-B27<sup>+</sup> JIA patients and HLA-B27<sup>-</sup> JIA patients. Our findings indicated that CCR7+/RELB+/IRF1+ positive T cells could damage the cartilage of HLA-B27<sup>+</sup> JIA by producing cytokines such as IL-17.
Authors
- Yue Lan (ORCID: https://orcid.org/0000-0003-2499-812X)
- Sha Lin (ORCID: https://orcid.org/0000-0001-9582-3306)
- Junling Guo (ORCID: https://orcid.org/0000-0002-2948-880X)
- Mingyi Lv
- Zhenxin Fan (ORCID: https://orcid.org/0000-0003-0422-9497)
- Xue Gong
- Yifei Li (ORCID: https://orcid.org/0000-0002-9177-5308)
- Xiaoliang Liu (ORCID: https://orcid.org/0000-0001-5878-3990)
- Lewei He (ORCID: https://orcid.org/0000-0001-6093-0451)
- Hui Guo (ORCID: https://orcid.org/0000-0001-9780-0845)
- Kaiyu Zhou (ORCID: https://orcid.org/0000-0002-0347-6317)
- Yimin Hua
Institutions
- Sichuan University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-08
- DOI
- https://doi.org/10.3389/fimmu.2025.1528446
- Primary Topic
- Autoimmune and Inflammatory Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00