A conceptual exploration on the synergistic anti-tumor effects of high-order combination of OHSV2-DSTEFAP5/CD3, CAR-T cells, and immunotoxins in hepatocellular carcinoma
This high-order combination represents a novel multiple-wave immunotherapeutic approach for HCC. Despite being a conceptual exploration, this strategy has demonstrated promising therapeutic efficacy and acceptable safety profiles.
Authors
- Le Huang
- Yuanxiang Li (ORCID: https://orcid.org/0009-0007-3905-4742)
- Mingqian Feng (ORCID: https://orcid.org/0000-0002-0654-8224)
- Fang Guo (ORCID: https://orcid.org/0000-0002-2792-8015)
- Xianmin Zhu (ORCID: https://orcid.org/0000-0003-1405-9700)
- Sheng Hu (ORCID: https://orcid.org/0000-0002-2709-6976)
- Binlei Liu (ORCID: https://orcid.org/0000-0002-2852-600X)
- Yang Wang (ORCID: https://orcid.org/0000-0003-0447-3107)
- Xin Chen (ORCID: https://orcid.org/0000-0002-9588-0164)
- Xiaoyu Li (ORCID: https://orcid.org/0000-0001-8017-207X)
- Jing Jin
- Shuang Dong (ORCID: https://orcid.org/0000-0002-8992-225X)
- Yi Zhong (ORCID: https://orcid.org/0000-0001-5584-0988)
- Chang Xue (ORCID: https://orcid.org/0000-0001-6990-214X)
- Qing Huang (ORCID: https://orcid.org/0000-0001-7253-3496)
- Qian Cai (ORCID: https://orcid.org/0000-0002-5700-3275)
Institutions
- Huazhong Agricultural University (CN)
- Wuhan YZY Biopharma (China) (CN)
- Hubei Cancer Hospital (CN)
- Huazhong University of Science and Technology (CN)
- Hubei University of Technology (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-08
- DOI
- https://doi.org/10.3389/fimmu.2025.1509087
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Health Commission of Hubei Province
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Natural Science Foundation of Hubei Province