Rutin ameliorates LPS-induced acute lung injury in mice by inhibiting the cGAS-STING-NLRP3 signaling pathway
These findings elucidate rutin's novel therapeutic mechanism through coordinated suppression of the cGAS-STING-NLRP3 axis, positioning it as a promising candidate for ALI/ARDS intervention.
Authors
- Min Luo (ORCID: https://orcid.org/0000-0003-0507-1687)
- Zhibin Wang (ORCID: https://orcid.org/0000-0002-7981-3666)
- Yuying Li (ORCID: https://orcid.org/0000-0002-0470-4887)
- Yuting Wang (ORCID: https://orcid.org/0009-0007-7345-0562)
- Guofeng Xu (ORCID: https://orcid.org/0000-0003-2164-2742)
- Xin Zhou (ORCID: https://orcid.org/0000-0001-6782-9313)
- Mengwei Zhang
Institutions
- Affiliated Hospital of Southwest Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-05-08
- DOI
- https://doi.org/10.3389/fphar.2025.1590096
- Citations
- 5
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 4.03
Funders
- Natural Science Foundation of Sichuan Province