Gut microbiota differences linked to weight gain and ART in people living with HIV are enterotype specific and minor compared to the large differences linked to sexual behavior
Differences in the composition and functional characteristics of the gut microbiome associated with weight gain and ART regimens were enterotype-specific and relatively small compared with differences linked to sexual orientation. Due to the substantial differences in gut microbiome structure among many MSM, categorization into enterotypes is useful for identifying differences in microbiome composition associated with variables such as weight gain or ART, which may be limited to a single enterotype. This may further advance the identification of microbes that contribute to weight gain or alter the gut microbiome composition in the context of the enterotype.
Authors
- Sarah Albayrak-Rena
- Jan Kehrmann (ORCID: https://orcid.org/0000-0002-1494-9191)
- Anna-Lena Stumpf
- Felix Maischack
- Alireza Dostmohammadi (ORCID: https://orcid.org/0000-0003-4311-2056)
- Farnoush Farahpour (ORCID: https://orcid.org/0000-0002-4510-8483)
- Stefanie Sammet
- Jan Buer (ORCID: https://orcid.org/0000-0002-7602-1698)
- Christina B. Karsten (ORCID: https://orcid.org/0000-0003-1934-6442)
- Stefan Eßer (ORCID: https://orcid.org/0000-0002-3625-9650)
- Folker Meyer (ORCID: https://orcid.org/0000-0003-1112-2284)
- Ivana Kraiselburd (ORCID: https://orcid.org/0000-0002-9677-6094)
- Lara Best
- Ann-Kathrin Doerr
- Katharina Bohlen
- Otgonzul von Velsen
- Leah Consten
- Hannah Sievert
Institutions
- Essen University Hospital (DE)
- University of Duisburg-Essen (DE)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-05-08
- DOI
- https://doi.org/10.3389/fcimb.2025.1568352
- Citations
- 2
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Deutsche Forschungsgemeinschaft
- Universität Duisburg-Essen