AQP9 weakens the cytotoxicity of CD8 <sup>+</sup> T cells in colon adenocarcinoma by boosting M2 polarization of macrophages under hypoxia conditions

AQP9 promotes COAD progression by driving HIF-1α-mediated M2 polarization, impairing CD8+ T cell function. Key limitations include the lack of <i>in vivo</i> validation and clinical cohort analysis.

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Publication Details

Journal
Expert Review of Clinical Immunology
Published
2025-05-07
DOI
https://doi.org/10.1080/1744666x.2025.2501718
Citations
2
Primary Topic
Immune cells in cancer
Type
article
Field-Weighted Citation Impact
1.59
Controls
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article

AQP9 weakens the cytotoxicity of CD8 + T cells in colon adenocarcinoma by boosting M2 polarization of macrophages under hypoxia conditions

J Chen, Shiyang Zhan, Yangqiang Wang, Pan Chi et al.
2 citations
Expert Review of Clinical Immunology
Immune cells in cancer
1.59
article

AQP9 weakens the cytotoxicity of CD8 + T cells in colon adenocarcinoma by boosting M2 polarization of macrophages under hypoxia conditions

J Chen, Shiyang Zhan, Yangqiang Wang, Pan Chi, Zongda Cai, Wei Zheng, Shurong Huang
article en
2 citations

Abstract

AQP9 promotes COAD progression by driving HIF-1α-mediated M2 polarization, impairing CD8+ T cell function. Key limitations include the lack of <i>in vivo</i> validation and clinical cohort analysis.

Expert Review of Clinical ImmunologyVol. 21(6)
Fujian Medical University (CN)
Zero hunger
Openalex Percentile: Top 17%
Immune cells in cancer
1.59
DOISourceOpenAlex
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AQP9 weakens the cytotoxicity of CD8 <sup>+</sup> T cells in colon adenocarcinoma by boosting M2 polarization of macrophages under hypoxia conditions — J Chen, Shiyang Zhan, et al. · Expert Review of Clinical Immunology (2025) | TGRS Research Map | TGRS