Whole genome sequencing reveals virulence–mobile element linkages and phylogenetic diversity in multidrug-resistant Escherichia coli from Nigeria
These findings underscore Nigeria's MDR-E crisis, driven by MGE-facilitated gene transfer, hybrid pathotypes, and globally disseminated high-risk clones harboring double-serine QRDR mutations. There is continued need for robust genomic surveillance, stringent infection control measures, enhanced antibiotic stewardship, and exploration of antivirulence strategies (e.g., targeting <i>fimH</i> or <i>yeh</i>) to curb the spread of these highly adaptable pathogens in resource-limited settings and beyond.
Authors
- Kenneth Iregbu (ORCID: https://orcid.org/0000-0003-4780-0497)
- Pallavi Singh (ORCID: https://orcid.org/0000-0002-0283-7459)
- Philip Nwajiobi-Princewill
- Siddhartha Thakur (ORCID: https://orcid.org/0000-0003-3787-9939)
- Stephen Obaro (ORCID: https://orcid.org/0000-0002-7526-1075)
- Lyndy Harden
- Abiodun Egwuenu (ORCID: https://orcid.org/0000-0002-9369-4771)
- Mabel Kamweli Aworh (ORCID: https://orcid.org/0000-0003-4213-6929)
- Nubwa Medugu (ORCID: https://orcid.org/0000-0002-1300-7362)
- Yahaya Mohammed (ORCID: https://orcid.org/0000-0003-0075-9511)
- Dawn Hull
- Leonard Ighodalo Uzairue (ORCID: https://orcid.org/0000-0003-2547-175X)
- Ruth Egah
- Faith Adeboye
- Nwafia Ifeyinwa
Institutions
- Northern Illinois University (US)
- Northwestern University (US)
- University of Nigeria (NG)
- North Carolina State University (US)
- Fayetteville State University (US)
- University of Alabama at Birmingham (US)
- National Hospital Abuja (NG)
- Northwestern University (PH)
- Federal Medical Centre (NG)
- Nigeria Centre for Disease Control (NG)
- Nile University of Nigeria (NG)
- Usmanu Danfodiyo University (NG)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-05-07
- DOI
- https://doi.org/10.3389/fmicb.2025.1579175
- Citations
- 10
- Primary Topic
- Escherichia coli research studies
- Type
- article
- Field-Weighted Citation Impact
- 17.98
Funders
- North Carolina State University