Long-term self-reported symptoms and psychophysical tests in COVID-19 subjects experiencing persistent olfactory dysfunction: a 4-year follow-up study
Our findings show that, despite most individuals with C19OD recover olfaction within the first year, a subset of them continue to experience prolonged CD, demonstrating a slow, constant and meaningful improvement over years. This prolonged recovery period highlights the complexity of SARS-CoV-2's impact on olfactory function and highlights the need of further research on CD pathophysiology with the aim to improve therapeutic approaches to C19OD.
Authors
- Sonny Zampollo
- Piero Nicolai
- Arabella Fontana
- Tommaso Saccardo (ORCID: https://orcid.org/0000-0002-8349-9569)
- Rosario Marchese‐Ragona (ORCID: https://orcid.org/0000-0001-6269-961X)
- Giancarlo Ottaviano (ORCID: https://orcid.org/0000-0003-2433-4761)
- Carla Mucignat‐Caretta (ORCID: https://orcid.org/0000-0001-5307-0414)
- Alfonso Luca Pendolino (ORCID: https://orcid.org/0000-0002-6348-5303)
- Bruno Scarpa (ORCID: https://orcid.org/0000-0002-9628-5164)
- Giuseppe Roccuzzo (ORCID: https://orcid.org/0000-0001-6731-8054)
Institutions
- University of Padua (IT)
- University College London (GB)
Publication Details
- Journal
- Frontiers in Neural Circuits
- Published
- 2025-05-07
- DOI
- https://doi.org/10.3389/fncir.2025.1538821
- Citations
- 1
- Primary Topic
- Olfactory and Sensory Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.46