The mechanism of electroacupuncture-mediated improvement in Parkinson’s disease by inhibiting ferroptosis through activating the Nrf2/GPX4 signal pathway
These findings demonstrate that EA exerts neuroprotection in PD by inhibiting ferroptosis through activation of the Nrf2/SLC7A11/FTH1/GPX4 signaling axis. This study not only elucidates a novel mechanism underlying EA's efficacy in PD but also highlights ferroptosis modulation as a therapeutic strategy, bridging traditional medicine with molecular pathophysiology. This study has provided new ideas for exploring the mechanism of EA in PD treatment.
Authors
- Ming Zhao (ORCID: https://orcid.org/0000-0002-7539-3887)
- He-Sheng Zheng
- Weiyu Ye (ORCID: https://orcid.org/0000-0002-8983-0355)
- Yumei Wu (ORCID: https://orcid.org/0000-0002-8524-1254)
- Shui‐bing Liu (ORCID: https://orcid.org/0000-0002-9325-3474)
- Min Wang (ORCID: https://orcid.org/0000-0003-0560-1983)
- Kun Zhang (ORCID: https://orcid.org/0000-0002-8268-1051)
- Rui Liu (ORCID: https://orcid.org/0000-0002-7812-966X)
- Le Yang
- Jin-Dong Mao
Institutions
- Tang Du Hospital (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-05-07
- DOI
- https://doi.org/10.3389/fnagi.2025.1551404
- Citations
- 1
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.52