Epidemiology and resistance mechanisms of tigecycline- and carbapenem-resistant Enterobacteriaceae in China: a multicentre genome-based study
The overall carriage rate of the <i>tmexC2D2-toprJ2</i> gene cluster was found to be low among the five Chinese hospitals investigated. Conversely, <i>tet</i>(A) mutations were present in most of the strains. Bacteria with the carbapenem resistance genes <i>bla</i> <sub>KPC</sub> and <i>bla</i> <sub>NDM</sub> are vulnerable to horizontal transmission. Increasing the risk of transmission of antibiotic-resistant genes.
Authors
- Zhongju Chen (ORCID: https://orcid.org/0000-0003-0606-3275)
- Jia Wei (ORCID: https://orcid.org/0000-0001-9621-529X)
- Lixin Yan
- Renru Han (ORCID: https://orcid.org/0009-0000-5266-515X)
- Hong Du (ORCID: https://orcid.org/0000-0002-2973-1523)
- Wen Wang (ORCID: https://orcid.org/0000-0002-0419-1508)
- Gang Li (ORCID: https://orcid.org/0000-0001-6778-2842)
- Zhen Cai (ORCID: https://orcid.org/0000-0001-6026-3804)
- Tao Jia (ORCID: https://orcid.org/0000-0003-0536-966X)
- Tingting Ma (ORCID: https://orcid.org/0000-0003-2441-5852)
- Yan Guo (ORCID: https://orcid.org/0000-0002-0394-3747)
Institutions
- Fudan University (CN)
- Soochow University (CN)
- Second Affiliated Hospital of Soochow University (CN)
- Ningxia Medical University (CN)
- Ningxia Medical University General Hospital (CN)
- Huashan Hospital (CN)
- Tongji Hospital (CN)
- Aviation General Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-05-07
- DOI
- https://doi.org/10.3389/fmicb.2025.1582851
- Citations
- 2
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 1.18
Funders
- Natural Science Foundation of Ningxia Province