Activity of Crude Phenolic Extract from Trigonella to Reduce Side Effect of Paclitaxel Drag on Chromosomal Aberrations, Sperm Parameters and Sperm DNA Fragmentation

Phenols are used to make detergents, a number of prescription medications, herbicides, and other industrial manufactured products. Because they are antioxidants, consuming a collection of phenolic ingredients contained in food lowers the risk of health problems. Paclitaxel is frequently employed in the management of various cancers. High doses of paclitaxel have been demonstrated to be more effective against several forms of cancer. But it has harmful effects on the reproductive system of male. One method of reducing paclitaxel side effects is to administer the medication along with an antioxidant Methodology: eighteen albino male rats were divided in to 3 groups. Each group contains 6 rats: Group one: Negative control with normal saline injected intraperitoneal. Group tow: Positive control Paclitaxel (4 doses at 7mg/kg in 28 days) without plants extract treated. Group three: Animals were treated with Paclitaxel and crude phenols extract of fenugreek at 10 mg/Kg administration orally then samples are collected after 28 days. Results: this result showed that phenols extract reduced chromosomal aberrations and DNA fragmentation, while increased sperm parameters Conclusion: in this work, we investigate the potential benefits of phenols extract from fenugreek to combat side effects of the chemotherapeutic agent paclitaxel.