Hybrid Skin Booster Injectables Hyaluronic Acid with Growth Factors and/or Hyper Diluted Calcium Hydroxyapatite “For Treating Facial Skin Pigmentations”

Background: Hyaluronic acid has an important role in skinviscoelasticity.Objective: The present study was performed to evaluateThe effect of injecting the non-cross-linked hyaluronic acid withgrowth factors and/or hyper-diluted calcium hydroxyapatite fortreating facial skin pigmentations and face rejuvenation, includingtexture, elasticity, and firmness through collagen induction.Methods: 30 female patients who suffered from dry skinwith pigmentations, were included in the study. All patientswere randomly divided into three groups; the first group wasinjected with non-cross-linked hyaluronic acid with growth factors,And the second group was injected with hyper-diluted calciumhydroxyapatite filler, while the third group was injectedwith a hybrid mixture of non-cross-linked hyaluronic acid withgrowth factors and hyper-diluted calcium hydroxyapatite filler.Digital pictures were taken before the injection and immediatelyAfter the injection for assessment of the clinical resultsas well as during the follow-up periods (2 weeks, 1 month &3 months).Results: The third group showed a marked reduction inThe amount of skin pigmentation at 2 weeks after injectionalong with improvement in the skin texture and elasticity, thoseChanges remained stable up to three months after treatment.Conclusion: The use of a hybrid mixture of non-crosslinked hyaluronic acid with growth factors & calcium hydroxyapatiteFiller provides a marked reduction in the amountof facial pigmentations and provides a better skin texture thanThe use of each product alone.