Study of Some Immunological Disorders Associated with Polycystic Ovary Syndrome

Background: Five to fifteen percent of females in reproductive age have polycystic ovarian syndrome, a hormonal disorder that may be linked to immune system problems. Objective: our study aim of Examine changes of certain immunological markers and their role in the progress in polycystic ovary syndrome in Iraqi women. Methodology: A total of 90 Iraqi women, ranging in age from 18 to 40 years, were included in the study. Of them, 46 had polycystic ovary syndrome (PCOS), while the other 44 served as a control group. blood samples were collected from all participants for the assessment of selected immunological markers. The serum levels of MCP-1, MIF, TNF, IL-6, IL-18, CRP, and 8-OHDG were measured using the Enzyme-Linked Immunosorbent Assay (ELISA) technique, following the manufacturer’s instructions. Results: In PCOS, for women, all inflammatory markers, with the exception of 8-OHDG, are significantly higher in comparison to control women. These indicators include MCP-1, MIF, TNF, IL-6, IL-18, and CRP. BMI and age show positive association with the majority of inflammatory markers, this gives credibility to the idea that female with PCOS, who are older and overweight, are more likely to have elevated inflammatory levels. In comparison to the women with polycystic ovary syndrome and control group, exhibited considerably greater ranges of MCP-1 (67.21 ng/ml) than the control group (58.92 ng/ml). PCOS women exhibited significantly higher MIF levels (9.67 ng/ml) compared to control women (8.05 ng/ml). PCOS women had significantly higher TNF levels (27.52 pg/ml) compared to control women (21.03 pg/ml). PCOS women showed significantly higher IL-6 levels (6.2 ng/ml) compared to control women (4.14 ng/ml). PCOS women had significantly higher IL-18 levels (12.34 ng/ml) compared to control women (10.54 ng/ml). PCOS women had dramatically higher CRP levels (5.52 mg/dl) compared to control women (2.55 mg/dl). Interestingly. PCOS women had significantly lower 8-OHDG levels (176.41 pg/ml) compared to control women (216.5 pg/ml). Conclusion: The levels of inflammatory markers were significantly different between the control groups and the women who were diagnosed with polycystic ovarian syndrome (PCOS).