Role of GENEXpert MTB/RIF in the Diagnosis of Tuberculosis Experience of the Central Laboratory of CHU Hassan II in Fez

Introduction Tuberculosis (TB) remains a major infectious disease, causing millions of deaths annually. The GeneXpert MTB/RIF, based on real-time PCR, provides rapid and reliable diagnosis while also detecting rifampicin resistance. Materials and Methods : This article presents the experience of the central laboratory at CHU Hassan II in Fez in diagnosing tuberculosis over a 12-month period, from December 2023 to December 2024. Results Among 507 samples, 65 (12.8%) were TB-positive. The majority were sputum samples (53.8%), followed by cerebrospinal fluid and peritoneal fluid. No rifampicin resistance was detected. Conclusion The GeneXpert MTB/RIF is a high-performance tool with elevated sensitivity, including in extrapulmonary TB. Its implementation enables faster diagnosis and improved patient management.