JOB: Japan Omics Browser provides integrative visualization of multi-omics data
We present the Japan Omics Browser (JOB), which enables integrative analysis of human omics at different layers. JOB offers visualization of per-variant regulatory effects in the human blood at mRNA and protein level distinctively, quantified from statistical fine-mapping of mRNA-expression quantitative loci (eQTL) and protein QTLs (pQTLs) in 1,405 Japanese, together with fine-mapping results of 94 complex traits in UK Biobank. In addition, JOB shows per-tissue regulatory effect prediction score (EMS), trained via multi-task learning. Furthermore, validation scores from Massively Parallel Reporter Assay (MPRA) in two cell types are available for over 10,000 variants. JOB is publicly available at https://japan-omics.jp/ .
Authors
- Yugo Takahashi (ORCID: https://orcid.org/0009-0005-2252-431X)
- Fumitaka Inoue (ORCID: https://orcid.org/0000-0003-0657-434X)
- Yukinori Okada (ORCID: https://orcid.org/0000-0002-0311-8472)
- Ho Namkoong (ORCID: https://orcid.org/0000-0001-6181-4284)
- Takanori Hasegawa (ORCID: https://orcid.org/0000-0001-7251-9950)
- Qingbo S. Wang (ORCID: https://orcid.org/0000-0002-9110-5830)
- Koichi Fukunaga (ORCID: https://orcid.org/0000-0001-7460-1990)
- Satoru Miyano (ORCID: https://orcid.org/0000-0002-1753-6616)
- Seiya Imoto (ORCID: https://orcid.org/0000-0002-2989-308X)
Institutions
- Keio University (JP)
- Kyoto University (JP)
- Tokyo Metropolitan Institute of Medical Science (JP)
- The University of Tokyo (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- BMC Genomics
- Published
- 2025-05-07
- DOI
- https://doi.org/10.1186/s12864-025-11639-1
- Primary Topic
- Bioinformatics and Genomic Networks
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Takeda Science Foundation
- Uehara Memorial Foundation
- Japan Agency for Medical Research and Development
- Ono Pharmaceutical
- Japan Society for the Promotion of Science
- Moonshot Research and Development Program