The association between stage migration and overall survival after radiation-based therapies in patients with hepatocellular carcinoma
Stage migration in patients with receiving hepatocellular carcinoma (HCC) treatment is a multi-faceted measure of tumor function, functional status, and liver function. In this study we were able to show that worsening Barcelona Clinic Liver Cancer stage within 6 months of receipt of radiation treatment is associated with overall survival. Stage migration could be further explored as an endpoint in future clinical trials in patients with HCC receiving radiation therapies.
Authors
- Jared A. Christensen (ORCID: https://orcid.org/0009-0008-3404-5238)
- Andrew M. Moon (ORCID: https://orcid.org/0000-0001-7163-2062)
- Jonathan Melendez-Torres
- Nima Kokabi (ORCID: https://orcid.org/0000-0002-4569-2720)
- Aamir Ali (ORCID: https://orcid.org/0000-0002-8433-4328)
- Amit G. Singal (ORCID: https://orcid.org/0000-0002-1172-3971)
- Ted K. Yanagihara (ORCID: https://orcid.org/0000-0001-7123-0637)
- Shengchen Hao
- Alisa Likhitsup (ORCID: https://orcid.org/0000-0001-8191-9497)
- Ammar Sarwar (ORCID: https://orcid.org/0000-0003-2254-9881)
- Michael Mohnasky (ORCID: https://orcid.org/0000-0002-2536-0200)
- Neehar D. Parikh (ORCID: https://orcid.org/0000-0002-5874-9933)
- Sruthi Yekkaluri (ORCID: https://orcid.org/0000-0002-6246-6135)
- Theodore S. Lawrence (ORCID: https://orcid.org/0000-0002-4186-8821)
- Suraj Pai (ORCID: https://orcid.org/0000-0002-7179-4405)
- Anjana Pillai (ORCID: https://orcid.org/0000-0001-6783-2109)
- Jane Brown
- Muhammad Mohid Tahir (ORCID: https://orcid.org/0000-0003-2272-7545)
- Mishal Mendiratta‐Lala (ORCID: https://orcid.org/0000-0003-4055-916X)
- Mehnish Malik (ORCID: https://orcid.org/0000-0001-7373-8661)
- Isaiah Brown
- Mikin Patel (ORCID: https://orcid.org/0000-0001-8715-2063)
- Vir J Kalaria
Institutions
- University of North Carolina at Chapel Hill (US)
- Beth Israel Deaconess Medical Center (US)
- University of Michigan (US)
- Beth Israel Deaconess Hospital (US)
- University of Chicago (US)
- UNC Lineberger Comprehensive Cancer Center
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- JHEP Reports
- Published
- 2025-05-07
- DOI
- https://doi.org/10.1016/j.jhepr.2025.101434
- Citations
- 1
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.32
Funders
- Division of Cancer Prevention, National Cancer Institute
- National Cancer Institute