Synthesis of Stylissamide B, a Pro‐Rich Cyclic Heptapeptide Isolated From the Marine Sponge <i>Stylissa caribica</i>
Stylissamide B was successfully synthesized for the first time using Fmoc solid-phase peptide synthesis (Fmoc-SPPS) followed by cyclization in solution phase. The Fmoc-SPPS process was monitored using the reversible detection method for amino groups (ReD-A method). The linear peptide, Pro-Pro-Ile-Tyr-Pro-Phe-Pro, was cyclized to form stylissamide B. The spectral data obtained were in agreement with previously reported literature, thereby confirming the reliability of the synthetic method.
Authors
- Kenta Teruya (ORCID: https://orcid.org/0000-0002-0500-986X)
- Hiroyuki Konno (ORCID: https://orcid.org/0000-0002-6629-6102)
- Yitong Li (ORCID: https://orcid.org/0000-0003-3402-4484)
- Hao Ling (ORCID: https://orcid.org/0000-0002-7680-7244)
Institutions
- Yamagata University (JP)
- Tohoku University (JP)
Publication Details
- Journal
- Journal of Peptide Science
- Published
- 2025-05-07
- DOI
- https://doi.org/10.1002/psc.70028
- Citations
- 3
- Primary Topic
- Chemical Synthesis and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- Small Business Innovation Research
- National Agriculture and Food Research Organization
- Japan Science and Technology Agency
- Bio-oriented Technology Research Advancement Institution