Receptor subtype-dependent effects of propofol on metalloproteinase activity, NKG2D ligand expression, and NK cell-mediated cytotoxicity in breast cancer: an in vitro study
Our results demonstrate that propofol exerts receptor subtype-dependent effects on NK cell-mediated immunosurveillance in breast cancer cell lines, potentially mediated by changes in the transcription of NKG2D ligands rather than by alterations in MMP expression or their proteolytic activity.
Authors
- Jae‐Ho Bae (ORCID: https://orcid.org/0000-0002-7077-6555)
- Kah Young Lee
- S. H. Park (ORCID: https://orcid.org/0009-0006-7778-1986)
- Hyun-Su Ri (ORCID: https://orcid.org/0000-0002-7305-4144)
- Ah-Reum Cho (ORCID: https://orcid.org/0000-0002-7108-1384)
- Jae Rin Kim
- Soeun Jeon (ORCID: https://orcid.org/0000-0002-4009-6321)
- Hyeon Jeong Lee
Institutions
- Kyungpook National University Hospital (KR)
- Kyungpook National University (KR)
- Pusan National University Hospital (KR)
- Pusan National University (KR)
Publication Details
- Journal
- Korean journal of anesthesiology
- Published
- 2025-05-07
- DOI
- https://doi.org/10.4097/kja.25011
- Citations
- 1
- Primary Topic
- Cancer, Stress, Anesthesia, and Immune Response
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- National Research Foundation
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea