Impact of vaccination status on the clinical course and outcomes of acute COVID-19 period: data from the international registry "Dynamics Analysis of Comorbidities in SARS-CoV-2 Survivors" (AKTIV-4)

Aim. To assess the effectiveness of vaccination against Omicron and Delta variants according to the international registry "Dynamics Analysis of Comorbidities in SARS-CoV-2 Survivors" (AKTIV-4). Material and methods. The AKTIV-4 registry included men and women over 18 years of age with a diagnosis of coronavirus disease 2019 (COVID-19) (oropharyngeal and nasopharyngeal swabs, SARS-CoV-2 antibody titers, typical computed tomography performance), undergoing hospital treatment. A total of 3543 patients from 25 medical centers in 7 countries (the Russian Federation, the Republic of Armenia, the Republic of Belarus, the Republic of Kazakhstan, the Kyrgyz Republic, the Republic of Moldova, and the Republic of Uzbekistan) were included in the AKTIV-4 registry. Results. The clinical status of patients from the AKTIV-4 registry was more severe than in the AKTIV-1 and AKTIV-2 registries. Patients in the AKTIV-4 registry were older than patients in the AKTIV-1 registry. The inhospital mortality rate in patients in the AKTIV-4 registry was higher (8,41%, p<0,001) than in the population of patients in the AKTIV-1 (7,60%) and AKTIV-2 (4,80%) registries. Of the 3543 patients included in AKTIV-4, 36% were vaccinated. Among the vaccines, Sputnik V (GamCOVID-Vac) was the leader in primary and repeated vaccination, used in 77,8% and 61,0%, respectively. In the population of unvaccinated patients, there were more patients with a high risk of an unfavorable prognosis than in the vaccinated as follows: older age, coronary artery disease, class 3-4 heart failure, atrial fibrillation, chronic kidney disease, and anemia. Unvaccinated patients had a higher volume of lung damage compared to vaccinated patients, and bacterial pneumonia and acute respiratory distress syndrome developed more often. Among those who died in hospital, unvaccinated patients predominated (89,14%). Inhospital mortality for unvaccinated patients was 9,9%, while for vaccinated ones — 3,3% (odds ratio (OR) 0,31 [0,20;0,45], p<0,001). In patients within 3, 4-6, and ≥7 months after vaccination, the mortality rate was 3,12% (OR 0,30 [0,16;0,51], p<0,001), 4,00% (OR 0,39 [0,20;0,67], p<0,001), and 2,96% (OR 0,29 [0,09;0,70], p<0,001). Inhospital mortality of vaccinated patients did not differ significantly depending on the type of vaccine. Conclusion. Vaccination, primarily with Sputnik V, is an independent predictor of survival in hospitalized COVID-19 patients and reduces the risk of death by 62% according to multivariate analysis.

Authors

S. Y. Sherbakov
Н. М. Никитина (ORCID: https://orcid.org/0000-0002-0313-1191)
Е. И. Горшенина (ORCID: https://orcid.org/0000-0001-9342-0909)
Sergey Vladimirovich Nedogoda (ORCID: https://orcid.org/0000-0001-5981-1754)
Marina Yarigina (ORCID: https://orcid.org/0000-0002-2437-3608)
I. V. Bikushova (ORCID: https://orcid.org/0000-0002-4152-4885)
А. И. Чесникова (ORCID: https://orcid.org/0000-0002-9323-592X)
И. В. Демко (ORCID: https://orcid.org/0000-0001-8982-5292)
D. A. Trofimov (ORCID: https://orcid.org/0000-0001-7613-7132)
Е. С. Годунко (ORCID: https://orcid.org/0000-0001-7528-9468)
Д. А. Синкевич (ORCID: https://orcid.org/0000-0003-3246-1357)
И. А. Каретников (ORCID: https://orcid.org/0000-0002-0922-6925)
Sarkis Ghazaryan
Д. С. Евдокимов (ORCID: https://orcid.org/0000-0002-3107-1691)
Н. М. Селезнева (ORCID: https://orcid.org/0000-0002-3004-2063)
S. H. Hamidov (ORCID: https://orcid.org/0000-0002-9452-1776)
V. V. Genkel (ORCID: https://orcid.org/0000-0001-5902-3803)
А. О. Рубаненко (ORCID: https://orcid.org/0000-0002-3996-4689)
S. T. Ualieva
T. I. Chudinovskikh (ORCID: https://orcid.org/0000-0002-7515-2215)
Z. F. Kim (ORCID: https://orcid.org/0000-0003-4240-3329)
D. S. Polyakov (ORCID: https://orcid.org/0000-0001-8421-0168)
Т. М. Левина (ORCID: https://orcid.org/0000-0002-7578-9160)
I. A. Zolotovskaya (ORCID: https://orcid.org/0000-0002-0555-4016)
K. Viktorov (ORCID: https://orcid.org/0000-0002-4203-6138)
V. D. Ma-Van-de (ORCID: https://orcid.org/0000-0001-6539-802X)
Д. Н. Зайцев (ORCID: https://orcid.org/0000-0002-2741-3783)
A. Matuzkova
Н. А. Кароли (ORCID: https://orcid.org/0000-0002-7464-826X)
N. V. Mukhа (ORCID: https://orcid.org/0000-0001-8128-636X)
O. Yu. Martynova (ORCID: https://orcid.org/0000-0002-9177-3388)
Farida Rustamova (ORCID: https://orcid.org/0000-0002-5259-6171)
N. B. Moiseenko (ORCID: https://orcid.org/0000-0003-2072-6370)
A. G. Arutyunov (ORCID: https://orcid.org/0000-0003-1180-3549)
A. I. Girivenko (ORCID: https://orcid.org/0000-0002-6882-7501)
D. A. Sh'ukarev
O. Yu. Barysheva (ORCID: https://orcid.org/0000-0002-2133-4849)
N. A. Lyubavina (ORCID: https://orcid.org/0000-0002-8914-8268)
A. A. Korolev
Sh. O. Ospanova (ORCID: https://orcid.org/0000-0003-2335-7232)
А. S. Galyavich (ORCID: https://orcid.org/0000-0002-4510-6197)
M. V. Kazakovtseva (ORCID: https://orcid.org/0000-0002-0981-3601)
K. R. Vagapova
D. Yu. Ruzanov (ORCID: https://orcid.org/0000-0001-5291-4937)
Н. Н. Везикова (ORCID: https://orcid.org/0000-0002-8901-3363)
Л. Н. Хусаинова (ORCID: https://orcid.org/0000-0002-5590-7270)
О. А. Рубаненко (ORCID: https://orcid.org/0000-0001-9351-6177)
Т. И. Батлук (ORCID: https://orcid.org/0000-0002-0210-2321)
О. В. Хлынова (ORCID: https://orcid.org/0000-0003-4860-0112)
Е. А. Смирнова (ORCID: https://orcid.org/0000-0003-0334-6237)
Yu. D. Zimina (ORCID: https://orcid.org/0000-0001-9027-6884)
A. S. Batchayeva
E. A. Stepina (ORCID: https://orcid.org/0000-0002-6176-4026)
Vasilen Vasilev
E. V. Grigoryeva (ORCID: https://orcid.org/0000-0001-6064-560X)
О.В. Машкунова (ORCID: https://orcid.org/0000-0002-8548-8281)
Ya. A. Belenikina
K. V. Kuzmichev
А. Yu. Kraposhina (ORCID: https://orcid.org/0000-0001-6896-877X)
К. В. Левченко (ORCID: https://orcid.org/0000-0002-0368-0473)
Ainur Sadykova (ORCID: https://orcid.org/0000-0003-4502-552X)
А. П. Ребров (ORCID: https://orcid.org/0000-0002-3463-7734)
О. В. Обухова (ORCID: https://orcid.org/0000-0001-9122-279X)
Ekaterina Shishkina (ORCID: https://orcid.org/0000-0001-6965-7869)
E. Yu. Ivanchenko (ORCID: https://orcid.org/0000-0003-4506-1053)
М. И. Колядич (ORCID: https://orcid.org/0000-0002-0168-1480)
А.I. Khaletskaya (ORCID: https://orcid.org/0000-0001-9730-8308)
Olga Fedorishina (ORCID: https://orcid.org/0000-0002-0155-676X)
Д. Н. Проценко (ORCID: https://orcid.org/0000-0002-5166-3280)
D. Yu. Konstantinov (ORCID: https://orcid.org/0000-0002-6177-8487)
А. С. Кузнецова (ORCID: https://orcid.org/0000-0002-1136-7284)
А. A. Tulichev (ORCID: https://orcid.org/0000-0002-3157-2218)
T.P. Abdualimov (ORCID: https://orcid.org/0000-0002-3158-8500)
Светлана Николаевна Ботова (ORCID: https://orcid.org/0000-0001-7085-2207)
N. D. Ulanova (ORCID: https://orcid.org/0000-0002-5107-6051)
R. A. Bashkinov (ORCID: https://orcid.org/0000-0001-9344-1304)
Александр Вячеславович Жарков (ORCID: https://orcid.org/0000-0001-6649-0928)
A. A. Ledyaeva (ORCID: https://orcid.org/0000-0003-4771-6025)
G. P. Arutyunov (ORCID: https://orcid.org/0000-0002-6645-2515)
A. V. Levshin (ORCID: https://orcid.org/0000-0002-3855-969X)
Наталья Юрьевна Григорьева (ORCID: https://orcid.org/0000-0001-6795-7884)
A. V. Agafonov (ORCID: https://orcid.org/0000-0003-2108-9051)
Elizaveta Gordeychuk (ORCID: https://orcid.org/0000-0002-6334-907X)
A. E. Zheldybaeva (ORCID: https://orcid.org/0000-0002-5347-3229)
L. S. Evdokimova (ORCID: https://orcid.org/0000-0002-7731-0109)
Е. А. Константинова (ORCID: https://orcid.org/0000-0002-6022-0983)
И. И. Шапошник (ORCID: https://orcid.org/0000-0002-7731-7730)
А. Р. Вайсберг (ORCID: https://orcid.org/0000-0003-3658-5330)
Akhmetzhan Sugraliyev (ORCID: https://orcid.org/0000-0002-8255-4159)
Amangul Duisenova (ORCID: https://orcid.org/0000-0002-3215-7382)
С. С. Пластинина (ORCID: https://orcid.org/0000-0002-0534-5986)
P. Seliverstov (ORCID: https://orcid.org/0000-0001-5623-4226)
D. V. Oblavatckii (ORCID: https://orcid.org/0000-0003-1628-0193)
А. В. Апаркина (ORCID: https://orcid.org/0000-0001-8463-2379)
Н. В. Ларева
Л. Л. Попова (ORCID: https://orcid.org/0000-0003-0549-361X)
E. S. Melnikov (ORCID: https://orcid.org/0000-0002-8521-6542)
Yu. A. Kravchuk (ORCID: https://orcid.org/0000-0001-8347-0531)
К. В. Протасов (ORCID: https://orcid.org/0000-0002-6516-3180)
Yu. M. Lopatin (ORCID: https://orcid.org/0000-0003-1943-1137)
E. I. Tarlovskaya (ORCID: https://orcid.org/0000-0002-9659-7010)
I. A. Tuchin (ORCID: https://orcid.org/0000-0002-8253-4625)
А. Г. Обрезан (ORCID: https://orcid.org/0000-0001-6115-7923)
Д. С. Каскаева (ORCID: https://orcid.org/0000-0002-0794-2530)
A. K. Abdrakhmanova (ORCID: https://orcid.org/0000-0002-6332-9503)
D. S. Tokmin (ORCID: https://orcid.org/0000-0003-1959-5940)
V. I. Maiseenko (ORCID: https://orcid.org/0000-0003-2133-4360)
М. М. Петрова (ORCID: https://orcid.org/0000-0002-8493-0058)
А. А. Толмачева (ORCID: https://orcid.org/0000-0003-1687-4100)
Н. В. Гордеева (ORCID: https://orcid.org/0000-0002-0586-8349)
V. L. Korobka (ORCID: https://orcid.org/0000-0002-6519-0162)
V. O. Bochkareva (ORCID: https://orcid.org/0000-0002-5345-5418)
Aigerim Z. Botabekova (ORCID: https://orcid.org/0000-0001-6694-2664)
S. V. Malchikova (ORCID: https://orcid.org/0000-0002-2209-9457)
D. V. Polyakov (ORCID: https://orcid.org/0000-0002-8738-6924)
A. V. Svarovskaya (ORCID: https://orcid.org/0000-0001-7834-2359)
V. A. Pogrebetskaya (ORCID: https://orcid.org/0000-0001-9407-3507)
И. Г. Починка (ORCID: https://orcid.org/0000-0001-5709-0703)
T. V. Kryukova
A. S. Makarova (ORCID: https://orcid.org/0000-0002-0486-9657)
А. O. Shabelsky
И. Л. Давыдкин (ORCID: https://orcid.org/0000-0002-4318-4247)
T. V. Lisun (ORCID: https://orcid.org/0000-0002-1616-4750)
E. V. Kozlov (ORCID: https://orcid.org/0009-0008-2206-1505)
S. Serikbolkyzy (ORCID: https://orcid.org/0000-0002-6355-2617)
M. A. Trubnikova (ORCID: https://orcid.org/0000-0003-4116-096X)
G. A. Bykova (ORCID: https://orcid.org/0000-0003-0823-4605)
Arman Hovakimyan
Yu. I. Lebedeva (ORCID: https://orcid.org/0000-0002-3512-2214)
Л. А. Балыкова (ORCID: https://orcid.org/0000-0002-2290-0013)
E. I. Suchkova (ORCID: https://orcid.org/0000-0002-7997-0338)
E. Yu. Gubareva (ORCID: https://orcid.org/0000-0001-6824-3963)
N. B. Kosacheva (ORCID: https://orcid.org/0000-0001-5178-4851)
I. A. Soloveva (ORCID: https://orcid.org/0000-0002-1999-9534)
I. A. Obukhova (ORCID: https://orcid.org/0000-0002-3286-4335)
Е. В. Макарова (ORCID: https://orcid.org/0000-0003-4394-0687)
E. S. Kim
В. Б. Гриневич (ORCID: https://orcid.org/0000-0002-1095-8787)
И. В. Губарева (ORCID: https://orcid.org/0000-0003-1881-024X)
В. В. Цома (ORCID: https://orcid.org/0000-0002-0662-1217)
N. А. Magdeeva (ORCID: https://orcid.org/0000-0002-6397-3542)
O. A. Rusinova (ORCID: https://orcid.org/0009-0009-8956-2985)
S. V. Pereverzev (ORCID: https://orcid.org/0000-0002-9426-8942)
L. N. Khokhlova (ORCID: https://orcid.org/0000-0002-3903-5652)
M. V. Popov (ORCID: https://orcid.org/0000-0002-2560-5204)
Е. В. Пономаренко
M. V. Lyubimov
O. A. Mazhara
A. O. Shvidko
S. S. Shostak-Krickii (ORCID: https://orcid.org/0000-0002-8901-6353)
V. G. Hakobjanyan
L. N. Allahkuliyeva
O. P. Girich
A. K. Izhanova (ORCID: https://orcid.org/0000-0003-0589-0148)
M. K. Kaidarbek (ORCID: https://orcid.org/0000-0003-4253-9138)
V. Yo. Koliev (ORCID: https://orcid.org/0000-0003-2936-6404)
A. K. Konussova (ORCID: https://orcid.org/0000-0002-0360-0584)
A. V. Korobka (ORCID: https://orcid.org/0000-0002-8204-401X)

Institutions

Privolzhsky Research Medical University (RU)
Russian Academy of Sciences (RU)
Novosibirsk State Medical University (RU)
Volgograd State Medical University (RU)
Rostov State Medical University (RU)
Gomel State Medical University (BY)
Illumina (United States) (US)
Kazan State Medical University (RU)
Kazakh National Medical University (KZ)
Petrozavodsk State University (RU)
S. M. Kirov Military Medical Academy (RU)
Chelyabinsk State Medical Academy (RU)
National Research Mordovia State University (RU)
Pirogov Russian National Research Medical University (RU)
Perm State Medical Academy (RU)
Krasnoyarsk State Medical University (RU)
Ural State Medical University (RU)
Children's City Policlinic No. 45 (RU)
St. Petersburg State Medical Academy "City Hospital No. 26" (RU)
National Institute of Health Sciences (LK)
St. Petersburg State Budgetary Healthcare Institution "City Polyclinic No. 106" (RU)
Ministry of Health of the Russian Federation (RU)
Saratov State Medical University (RU)
Tomsk National Research Medical Center (RU)
City Hospital (GB)
Irkutsk Regional Clinical Hospital (RU)
Krasnoyarsk Regional Clinical Hospital (RU)
Kirov State Medical Academy (RU)
Samara State Medical University (RU)
Infectious Clinical Hospital No. 1 (RU)
City Clinical Hospital (RU)
St. Petersburg State Medical Academy "City Polyclinic №44" (RU)
Ryazan State Medical University named after Academician I.P. Pavlov (RU)
State Autonomous Institution of Health Interregional Clinical Diagnostic Center (RU)
Autonomous Healthcare (US)
LogicMill Technology (United States) (US)
North-Western State Medical University named after I.I. Mechnikov (RU)
St. George Hospital (IN)
Irkutsk State Medical University (RU)
Chita State Academy of Medicine (RU)
Saint Petersburg State Pediatric Medical University (RU)
N. I. Lobachevsky State University of Nizhny Novgorod (RU)

Publication Details

Journal: Russian Journal of Cardiology
Published: 2025-04-29
DOI: https://doi.org/10.15829/1560-4071-2025-6010
Primary Topic: SARS-CoV-2 and COVID-19 Research
Type: article
Field-Weighted Citation Impact: 0.00

Impact of vaccination status on the clinical course and outcomes of acute COVID-19 period: data from the international registry "Dynamics Analysis of Comorbidities in SARS-CoV-2 Survivors" (AKTIV-4)

Authors

Institutions

Publication Details

Impact of vaccination status on the clinical course and outcomes of acute COVID-19 period: data from the international registry "Dynamics Analysis of Comorbidities in SARS-CoV-2 Survivors" (AKTIV-4)

Impact of vaccination status on the clinical course and outcomes of acute COVID-19 period: data from the international registry "Dynamics Analysis of Comorbidities in SARS-CoV-2 Survivors" (AKTIV-4)

Abstract

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