Prospects for a pharmacoinvasive strategy in ST-elevation myocardial infarction in the Russian Federation

In patients with ST-elevation myocardial infarction, primary percutaneous coronary intervention should be performed within 120 minutes after diagnosis if possible. Timely revascularization helps to preserve left ventricular function, minimizing myocardial damage, which subsequently reduces disability and mortality. There are patients for whom this approach cannot be implemented within the specified time frame for a number of reasons. In such a situation, a pharmacoinvasive strategy is recommended, which involves thrombolytic therapy as the first stage. Current treatment strategies for myocardial infarction have been compared many times. An undoubted advantage in Russia is the availability of domestic staphylokinase agent, which has a good efficacy and safety profile, meeting the requirements for fibrin specificity. Thus, research determining the current place of pharmacoinvasive strategy should be continued to optimize thrombolysis and improve the prognosis in patients with myocardial infarction.

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Publication Details

Journal
Russian Journal of Cardiology
Published
2025-04-29
DOI
https://doi.org/10.15829/1560-4071-2025-6290
Citations
2
Primary Topic
Acute Myocardial Infarction Research
Type
article
Field-Weighted Citation Impact
2.78
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article

Prospects for a pharmacoinvasive strategy in ST-elevation myocardial infarction in the Russian Federation

A. N. Yakovlev, Irina Avdeeva, Р. М. Шахнович, V. E. Oleynikov et al.
2 citations
Russian Journal of Cardiology
Acute Myocardial Infarction Research
2.78
article

Prospects for a pharmacoinvasive strategy in ST-elevation myocardial infarction in the Russian Federation

A. N. Yakovlev, Irina Avdeeva, Р. М. Шахнович, V. E. Oleynikov, R. M. Rabinovich
article en
2 citations

Abstract

In patients with ST-elevation myocardial infarction, primary percutaneous coronary intervention should be performed within 120 minutes after diagnosis if possible. Timely revascularization helps to preserve left ventricular function, minimizing myocardial damage, which subsequently reduces disability and mortality. There are patients for whom this approach cannot be implemented within the specified time frame for a number of reasons. In such a situation, a pharmacoinvasive strategy is recommended, which involves thrombolytic therapy as the first stage. Current treatment strategies for myocardial infarction have been compared many times. An undoubted advantage in Russia is the availability of domestic staphylokinase agent, which has a good efficacy and safety profile, meeting the requirements for fibrin specificity. Thus, research determining the current place of pharmacoinvasive strategy should be continued to optimize thrombolysis and improve the prognosis in patients with myocardial infarction.

Russian Journal of CardiologyVol. 30(3)
Penza State University (RU), Federal Almazov North-West Medical Research Centre (RU), Tver State Medical University (RU), National Medical Research Center of Cardiology (RU)
Openalex Percentile: Top 10%
Acute Myocardial Infarction Research
2.78
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Prospects for a pharmacoinvasive strategy in ST-elevation myocardial infarction in the Russian Federation — A. N. Yakovlev, Irina Avdeeva, et al. · Russian Journal of Cardiology (2025) | TGRS Research Map | TGRS