T-lymphocytes suppression by CD14+ monocytes with high expression of ULK2 in patients with multiple myeloma
We demonstrated that CD14<sup>+</sup> monocytes from MM can disrupt the delivery of antigenic peptides through the antigen processing and presentation pathway. This disruption affects T-lymphocytes activity and attenuates their ability to kill malignant cells and secrete cytokines. These findings lay the foundation for understanding the immuno-suppressive environment in MM, improving the efficacy of immunotherapy based on T-lymphocytes, and developing new therapeutic targets.
Authors
- Zhaoyun Liu (ORCID: https://orcid.org/0000-0002-2730-1562)
- Nanhao Meng (ORCID: https://orcid.org/0000-0002-6720-0416)
- Fengping Peng (ORCID: https://orcid.org/0000-0002-1761-1399)
- Nianbin Li (ORCID: https://orcid.org/0000-0003-2426-509X)
- Kai Ding (ORCID: https://orcid.org/0000-0002-5412-5453)
- Hui Liu (ORCID: https://orcid.org/0000-0002-7206-8747)
- Hao Wang (ORCID: https://orcid.org/0000-0001-9990-2714)
- Rong Fu (ORCID: https://orcid.org/0000-0002-9928-9224)
- Fengjuan Jiang (ORCID: https://orcid.org/0000-0002-3994-0513)
Institutions
- Tianjin Normal University (CN)
- Tianjin Chengjian University (CN)
- Tianjin Medical University General Hospital (CN)
- Tianjin People's Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-05-07
- DOI
- https://doi.org/10.1186/s12967-025-06516-0
- Citations
- 5
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 3.99
Funders
- Tianjin Municipal Health Commission
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Tianjin Science and Technology Committee
- Tianjin Municipal Education Commission
- Tianjin Science and Technology Program