The Global Trigger Tool in Psychiatry: A National Trigger Panel

Recent research increasingly addresses the safety issues of psychopharmacotherapy, particularly in connection with the need for long-term medication use in the treatment of mental disorders. In this context, the Global Trigger Tool (GTT) method serves as an effective instrument for monitoring adverse events, however, its application in psychiatry requires adaptation considering the specifics of this medical field and the organizational features of psychiatric care in Russia. This systematic review includes an analysis of 7 key studies conducted in Sweden, Norway, Singapore, the USA, and Russia, identified in PubMed, Google Scholar, and Elibrary databases (up to March 2025). The included articles describe both the application of the original methodology in psychiatry and attempts to modify it for this medical domain. Of particular interest are studies that attempted to adapt the GTT to the legal and cultural characteristics of national healthcare systems. All included studies demonstrated the value of this methodology for monitoring the safety of pharmacotherapy in psychiatric practice. Based on the obtained results and considering international experience, while taking into account the specifics of Russian psychiatric practice, the authors developed a specialized trigger panel during a dialogue conference. This panel enables the creation of a unified system for monitoring psychopharmacotherapy safety, which is especially relevant for Russian medical institutions. The implementation of this methodology can not only standardize the safety monitoring process but also significantly enhance the safety level of pharmacotherapy in the treatment of mental disorders in the Russian Federation .