Pharmacogenomics and Pharmacokinetics of Aspirin in Preeclampsia Prevention
Our study revealed that maternal genetic factors and plasma aspirin hydrolysis are not among the decisive factors in determining the effectiveness of low-dose aspirin in preventing preeclampsia among high-risk women. Instead, placental GLYAT appears to play a key role by limiting the effect of salicylic acid in the placenta.
Authors
- Mei Zhong (ORCID: https://orcid.org/0000-0002-5848-8219)
- Hon‐Cheong So (ORCID: https://orcid.org/0000-0002-7102-833X)
- Liona C. Poon (ORCID: https://orcid.org/0000-0002-3944-4130)
- Bo Wah Leung
- Long Nguyen‐Hoang (ORCID: https://orcid.org/0009-0006-6450-0241)
- Ruqun Zheng (ORCID: https://orcid.org/0000-0001-8498-8869)
- Chi Chiu Wang (ORCID: https://orcid.org/0000-0002-3928-7278)
- Kenean Getaneh Tlaye (ORCID: https://orcid.org/0000-0001-8464-4345)
- Yao Wang (ORCID: https://orcid.org/0000-0003-0010-2819)
- Xueqin Wang
- Kenneth Chi-Yin Wong (ORCID: https://orcid.org/0000-0001-5397-6224)
- Gashaw Garedew Woldeamanuel
- Lu Chen (ORCID: https://orcid.org/0000-0002-8426-3742)
- Yü Huang (ORCID: https://orcid.org/0000-0002-1277-6784)
- Pui Kin So
Institutions
- Hong Kong Polytechnic University (HK)
- City University of Hong Kong (HK)
- Chinese University of Hong Kong (HK)
- Wolkite University (ET)
- Chinese University of Hong Kong, Shenzhen (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Circulation Research
- Published
- 2025-05-07
- DOI
- https://doi.org/10.1161/circresaha.124.325699
- Citations
- 4
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 8.23