Automatised online SPE-LC-MS/MS method for the enantioselective determination of chiral β-blockers and antidepressants in wastewater
This method is the first one for online SPE-chiral-LC-MS/MS determination of two therapeutic groups of chiral pharmaceuticals in wastewater. The method allows their automatised enantiomeric determination, including sample treatment, SPE column wash and conditioning, and LC-MS/MS determination, in 40 min with enantioresolution from 0.51 to 1.24. The online SPE method developed provides a fast way to obtain information about chiral compounds in wastewater reducing labour intensity, exposure to organic solvents, analyte loss and plastic waste.
Authors
- Irene Aparicio (ORCID: https://orcid.org/0000-0002-5468-9021)
- Juan Luís Santos (ORCID: https://orcid.org/0000-0001-9704-1316)
- Julia Martı́n (ORCID: https://orcid.org/0000-0003-3621-1291)
- Marina Arenas (ORCID: https://orcid.org/0000-0003-1530-5985)
- Esteban Alonso (ORCID: https://orcid.org/0000-0002-1647-9226)
Institutions
- Universidad de Sevilla (ES)
Publication Details
- Journal
- Analytica Chimica Acta
- Published
- 2025-05-07
- DOI
- https://doi.org/10.1016/j.aca.2025.344152
- Citations
- 2
- Primary Topic
- Pharmaceutical and Antibiotic Environmental Impacts
- Type
- article
- Field-Weighted Citation Impact
- 1.01
Funders
- Consejería de Economía, Conocimiento, Empresas y Universidad, Junta de Andalucía
- European Commission
- Junta de Andalucía
- European Regional Development Fund