Accumulation of long-chain unsaturated fatty acids in the airway inflammatory microenvironment drives eosinophil etosis and corticosteroid resistance
Our findings demonstrate a previously unknown role of the LCFA arachidonic acid in mediating EETosis and glucocorticoid insensitivity to drive ENP progression, which may lead to novel insights regarding the treatment of patients with refractory eosinophilic inflammation.
Authors
- Xin Luo (ORCID: https://orcid.org/0000-0002-2809-5836)
- Wenlong Li (ORCID: https://orcid.org/0000-0001-6156-3390)
- Peining Fang
- Qintai Yang (ORCID: https://orcid.org/0000-0003-3377-737X)
- Deyu Fang (ORCID: https://orcid.org/0000-0002-4211-2751)
- Junhai Chen
- Shigeharu Ueki (ORCID: https://orcid.org/0000-0002-3537-7735)
- Yana Zhang (ORCID: https://orcid.org/0000-0003-4463-1827)
- Wei‐Qiang Huang (ORCID: https://orcid.org/0000-0002-2660-1117)
- Shasha Li (ORCID: https://orcid.org/0000-0003-1170-4591)
- Yue Li (ORCID: https://orcid.org/0000-0002-2353-4078)
- Xinyue Wang (ORCID: https://orcid.org/0000-0002-0863-8709)
- Jingyuan Chen (ORCID: https://orcid.org/0000-0003-4795-3856)
- Wenyi Chen
- Yurong Bai
- Zhe Xiao
Institutions
- Northwestern University (US)
- Sun Yat-sen University (CN)
- Akita University (JP)
- Key Laboratory of Guangdong Province (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-05-07
- DOI
- https://doi.org/10.1186/s12964-025-02217-9
- Citations
- 1
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- National Natural Science Foundation of China