Allelic variation in a cluster of epsilon glutathione S-transferase genes contributes to DDT and pyrethroid resistance in the major African malaria vector Anopheles funestus
These findings established the role of GSTes in conferring cross-resistance to pyrethroids and DDT, highlighting the role of these genes in metabolic resistance in An. funestus, which complicates malaria control using the above key insecticides.
Authors
- Sulaiman S. Ibrahim (ORCID: https://orcid.org/0000-0003-0744-802X)
- Charles S. Wondji (ORCID: https://orcid.org/0000-0003-0791-3673)
- Mersimine Kouamo (ORCID: https://orcid.org/0000-0003-0170-9516)
- Abdullahi Muhammad (ORCID: https://orcid.org/0000-0002-6438-4897)
- Jack Hearn (ORCID: https://orcid.org/0000-0003-3358-4949)
- Mahamat Gadji
Institutions
- Université de Yaoundé I (CM)
- Liverpool School of Tropical Medicine (GB)
- Ministry of Scientific Research and Innovation (CM)
- Bayero University Kano (NG)
Publication Details
- Journal
- BMC Genomics
- Published
- 2025-05-07
- DOI
- https://doi.org/10.1186/s12864-025-11637-3
- Citations
- 9
- Primary Topic
- Glutathione Transferases and Polymorphisms
- Type
- article
- Field-Weighted Citation Impact
- 7.25
Funders
- Bill and Melinda Gates Foundation
- Wellcome Trust