Silica Composites With Nickel In Situ <scp>PU</scp>/<scp>PVP</scp> Film for <scp>pH</scp>‐Responsive and <scp>ROS</scp>‐Stimulated Anticancer Drug Delivery System

ABSTRACT Increase in chemotherapy effect of drugs has remained a challenge for cancer curing. Improving an implantable drug delivery system with increased ROS activity and stimuli responsiveness could be a better choice. Focusing on flexibility, thermal stability, and biocompatibility, polyurethane can serve as an excellent material for variant applications. Surface modification is a feasible method for improving an ideal substrate. Blending polyvinylpyrrolidone (PVP) and incorporating green‐routed nanocomposite can enhance hydrophilicity, swellability, and biocompatibility. On analyzing the physicochemical changes, the SiNiO@PU/PVP film has lesser pore volume and porous nature than the Si@PU/PVP film; also, the major swelling ratio is higher for Si@PU/PVP. On correlating in vitro drug release and anticancer studies, the Si@PU/PVP film showed 92.3% release at 4.2 pH and 70% of THP‐1 cell death. Thus, comparing the Si@PU/PVP film can remarkably act as an implantable anticancer drug delivery system and water antipathogen or antimicrobial substrate.