Site-Selective Nitration of Arene via Hypervalent Iodine-Mediated C–H Functionalization
We developed a novel nitration method using hypervalent iodine for site-selective C-H functionalization. This technique efficiently synthesizes nitroarenes with high regioselectivity and is scalable, enhancing the late-stage modification of bioactive pharmaceuticals.
Authors
- Yanchuan Zhao (ORCID: https://orcid.org/0000-0002-2903-4218)
- Guangxing Gu
- Wenjing Bao
- Ziyang Zhang (ORCID: https://orcid.org/0000-0001-5870-704X)
- Zhenjiang Liu (ORCID: https://orcid.org/0000-0001-6850-9485)
Institutions
- Chinese Academy of Sciences (CN)
- Shanghai Institute of Organic Chemistry (CN)
- State Key Laboratory of Synthetic Chemistry (CN)
- University of Chinese Academy of Sciences (CN)
- Shanghai Institute of Technology (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-05-07
- DOI
- https://doi.org/10.1021/acs.orglett.5c00862
- Citations
- 6
- Primary Topic
- Oxidative Organic Chemistry Reactions
- Type
- article
- Field-Weighted Citation Impact
- 5.62
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- People's Government of Jilin Province