PD-1 Blockade Mitigates Surgery-Induced Immunosuppression and Increases the Efficacy of Photodynamic Therapy for Pleural Mesothelioma
Surgery combined with PDT extends survival for patients with mesothelioma, but these patients are still at risk for tumor recurrence, in part due to the immunosuppressive effects of surgery. We find, in a mouse model, that combining surgery, PDT, and immune checkpoint blockade maximizes the efficacy of these therapies.
Authors
- Shirron Carter (ORCID: https://orcid.org/0000-0003-1595-271X)
- Min Yuan (ORCID: https://orcid.org/0009-0002-3305-4294)
- Steven Μ. Albelda (ORCID: https://orcid.org/0000-0002-6598-3752)
- Gwendolyn M. Cramer (ORCID: https://orcid.org/0000-0002-1141-3391)
- Andrew V. Kossenkov (ORCID: https://orcid.org/0000-0002-1536-0418)
- Mary E. Putt (ORCID: https://orcid.org/0000-0001-7954-1288)
- Edmund K. Moon (ORCID: https://orcid.org/0009-0003-7597-8070)
- Astero Klampatsa (ORCID: https://orcid.org/0000-0003-0572-502X)
- Joann M. Miller (ORCID: https://orcid.org/0000-0003-2987-592X)
- Ruth Ikpe (ORCID: https://orcid.org/0009-0006-7579-1611)
- Emmanouil Papasavvas
- Sandy Widura (ORCID: https://orcid.org/0009-0005-7424-9356)
- Sally McNulty (ORCID: https://orcid.org/0009-0004-2347-4548)
- Luis J. Montaner (ORCID: https://orcid.org/0000-0001-5799-6759)
- Keith A. Cengel (ORCID: https://orcid.org/0000-0001-6960-5882)
- Richard W. Davis (ORCID: https://orcid.org/0000-0003-2193-493X)
- Theresa M. Busch (ORCID: https://orcid.org/0000-0002-5499-8377)
- R. Sonali Majumdar
- Sunil Kumar Singhal (ORCID: https://orcid.org/0000-0002-2413-7082)
Institutions
- The Wistar Institute (US)
- Institute of Cancer Research (GB)
- GlaxoSmithKline (United States) (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1158/2767-9764.crc-24-0571
- Primary Topic
- Occupational and environmental lung diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00