Synthesis and Transformations of O-Propargyl Analogues of Fusidic Acid

In continuation of our studies of modification of fusidane triterpenoids, O-propargyl fragment has been introduced at C3 of fusidic acid methyl ester, and the resulting O-propargyl ether was subjected to copper(I)-catalyzed transformations to obtain aminomethyl, phenylacetylene, and 1,2,3-triazole derivatives.

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Journal
Russian Journal of Organic Chemistry
Published
2025-03-01
DOI
https://doi.org/10.1134/s1070428024604618
Primary Topic
Microbial Natural Products and Biosynthesis
Type
article
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article

Synthesis and Transformations of O-Propargyl Analogues of Fusidic Acid

Е. В. Салимова, Lyudmila V. Parfenova, D. A. Golovnina
Russian Journal of Organic Chemistry
Microbial Natural Products and Biosynthesis
article

Synthesis and Transformations of O-Propargyl Analogues of Fusidic Acid

Е. В. Салимова, Lyudmila V. Parfenova, D. A. Golovnina
article en

Abstract

In continuation of our studies of modification of fusidane triterpenoids, O-propargyl fragment has been introduced at C3 of fusidic acid methyl ester, and the resulting O-propargyl ether was subjected to copper(I)-catalyzed transformations to obtain aminomethyl, phenylacetylene, and 1,2,3-triazole derivatives.

Russian Journal of Organic ChemistryVol. 61(3)
Ufa Institute of Chemistry (RU)
Openalex Percentile: Top 89%
Microbial Natural Products and Biosynthesis
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Synthesis and Transformations of O-Propargyl Analogues of Fusidic Acid — Е. В. Салимова, Lyudmila V. Parfenova, et al. · Russian Journal of Organic Chemistry (2025) | TGRS Research Map | TGRS