A 24-week prospective, multicenter, real-world study on eptinezumab’s effectiveness and safety in migraine prevention (EMBRACE II)
This real-world study documents that 24-week eptinezumab treatment is rapidly effective and well tolerated in migraine patients with multiple therapeutic failures (including anti-CGRP mAbs). One-third of patients escalated to 300 mg at week 12, achieving further significant migraine-related disability reduction.
Authors
- Massimo Filippi (ORCID: https://orcid.org/0000-0002-5485-0479)
- Cinzia Aurilia (ORCID: https://orcid.org/0000-0002-2658-2243)
- Piero Barbanti (ORCID: https://orcid.org/0000-0002-5670-3755)
- Roberta Messina (ORCID: https://orcid.org/0000-0003-4421-0432)
- Luisa Vinciguerra (ORCID: https://orcid.org/0000-0002-0710-2072)
- Davide Mascarella (ORCID: https://orcid.org/0000-0002-9265-3281)
- Sabina Cevoli (ORCID: https://orcid.org/0000-0003-4668-4295)
- Rosario Vecchio
- Francesca Pistoia (ORCID: https://orcid.org/0000-0003-0790-4240)
- Mattia Sansone (ORCID: https://orcid.org/0000-0002-1232-2651)
- Massimo Autunno (ORCID: https://orcid.org/0000-0002-7526-2799)
- Stefano Bonassi (ORCID: https://orcid.org/0000-0003-3833-6717)
- Giacomo Querzola (ORCID: https://orcid.org/0000-0002-9725-5370)
- Alessandro Valenza
- Gennaro Saporito (ORCID: https://orcid.org/0009-0001-2390-0533)
- Angelo Ranieri (ORCID: https://orcid.org/0000-0001-5450-1909)
- Giovanna Viticchi (ORCID: https://orcid.org/0000-0002-1799-1563)
- Luigi Caputi (ORCID: https://orcid.org/0000-0002-5724-1943)
- M. Poggio (ORCID: https://orcid.org/0000-0001-8871-1103)
- Antonio Salerno
- Paola Torelli (ORCID: https://orcid.org/0000-0002-4072-2353)
- Fabio Brusaferri
- Bianca Orlando
- Barbara Petolicchio (ORCID: https://orcid.org/0000-0003-2775-928X)
- Cecilia Camarda
- Gabriella Egeo (ORCID: https://orcid.org/0000-0003-3068-4522)
- Steno Rinalduzzi
- Alberto Doretti (ORCID: https://orcid.org/0000-0002-1015-7365)
- L. Borrello (ORCID: https://orcid.org/0000-0001-6801-7966)
- Francesca Gragnani
- Marisa Distefano (ORCID: https://orcid.org/0000-0002-7393-0941)
- Giulia Fiorentini
- Marco Bartolini (ORCID: https://orcid.org/0000-0003-2518-6369)
- Alice Mannocci (ORCID: https://orcid.org/0000-0002-8527-6940)
- Sofia Tavani
- Stefano Messina (ORCID: https://orcid.org/0000-0002-5150-7050)
- Paola Scatena
- Florindo d’Onofrio (ORCID: https://orcid.org/0009-0007-1647-3389)
- Antonio Carnevale (ORCID: https://orcid.org/0009-0005-5665-5780)
- Valeria Drago
- Francesco Baldisseri
Institutions
- University of Messina (IT)
- Marche Polytechnic University (IT)
- University of Parma (IT)
- Vita-Salute San Raffaele University (IT)
- University of L'Aquila (IT)
- Azienda Ospedaliera San Giovanni Addolorata (IT)
- Riverview Psychiatric Center (US)
- Agostino Gemelli University Polyclinic (IT)
- San Raffaele University of Rome (IT)
- Accademia di Belle Arti di Frosinone (IT)
- Ospedale Antonio Cardarelli (IT)
- Ellis Hospital (US)
- Ospedale San Filippo Neri (IT)
- Ospedale San Carlo (IT)
- Fatebenefratelli Hospital (IT)
- Azienda Ospedaliera S.Giuseppe Moscati (IT)
- Istituto delle Scienze Neurologiche di Bologna (IT)
- Ospedale di Belcolle (IT)
- IRCCS Ospedale San Raffaele (IT)
- IRCCS Istituto Auxologico Italiano (IT)
- Ospedale Sandro Pertini (IT)
- Azienda Ospedaliera Ospedale Maggiore (IT)
- Ospedale Policlinico San Martino (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT)
- University of Palermo (IT)
Publication Details
- Journal
- Journal of Neurology
- Published
- 2025-05-07
- DOI
- https://doi.org/10.1007/s00415-025-13095-z
- Citations
- 4
- Primary Topic
- Migraine and Headache Studies
- Type
- article
- Field-Weighted Citation Impact
- 5.88
Funders
- Ministero della Salute