Genomic surveillance reveals different transmission patterns between third-generation cephalosporin and carbapenem resistance in Klebsiella pneumoniae in the Comunidad Valenciana (Spain), 2018–2020
Different transmission patterns characterized the spread of 3GC- and carbapenem resistance in the region. While inter-hospital transmission played a significant role in the spread of 3GC-resistance, this was only sporadic for carbapenem resistance. Moreover, the factors behind inter-hospital spread for each type of resistance differed: while 3GC-resistance likely disseminated between hospitals through intermediate steps, carbapenem resistance was driven by more direct transmission routes. The burden of national and global cases on the ongoing regional AMR dissemination was low. Moreover, we revealed the rapid expansion in the region and globally of lineage ST307 carrying the bla<sub>CTX-M-15</sub> gene, a main driver of local transmissions, providing a deeper understanding of the successful spread of this high-risk clone.
Authors
- Salvador Giner
- Begoña Fuster (ORCID: https://orcid.org/0009-0007-4513-4546)
- Olalla Martínez
- Carme Salvador García (ORCID: https://orcid.org/0000-0002-8577-5934)
- David Navarro (ORCID: https://orcid.org/0000-0003-3010-4110)
- Nuria Tormo (ORCID: https://orcid.org/0000-0002-4514-7730)
- I. Vidal
- Victoria Sánchez (ORCID: https://orcid.org/0000-0002-4101-0120)
- Neris García‐González (ORCID: https://orcid.org/0000-0001-9089-4033)
- Victoria Domínguez Del Angel (ORCID: https://orcid.org/0000-0002-5514-6651)
- Bárbara Gomila-Sard (ORCID: https://orcid.org/0000-0003-2858-2711)
- Beatriz Beamud (ORCID: https://orcid.org/0000-0003-0863-3390)
- Javier Colomina (ORCID: https://orcid.org/0000-0003-1654-3619)
- Juan Carlos Rodrı́guez (ORCID: https://orcid.org/0000-0001-8007-5739)
- Jordi Sevilla-Fortuny
- Concepción Gimeno
Institutions
- Institut Pasteur (FR)
- Universitat de València (ES)
- Hospital Universitari i Politècnic La Fe (ES)
- Hospital de La Ribera (ES)
- Hospital Clínico Universitario de Valencia (ES)
- Centro de Investigación Biomédica en Red (ES)
- Hospital General Universitario de Elche (ES)
- Hospital Arnau de Vilanova (ES)
- Hospital General Universitari de Castelló (ES)
- Hospital General Universitario De Valencia (ES)
- Hospital General Universitario de Alicante Doctor Balmis (ES)
- Institute for Integrative Systems Biology (ES)
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (ES)
Publication Details
- Journal
- Antimicrobial Resistance and Infection Control
- Published
- 2025-05-07
- DOI
- https://doi.org/10.1186/s13756-025-01553-2
- Citations
- 5
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 2.96
Funders
- Generalitat Valenciana
- Universitat de València
- Ministerio de Ciencia e Innovación
- Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
- Conselleria de Cultura, Educación y Ciencia, Generalitat Valenciana