Ammonium Salts as Convenient Ammonia Surrogates in the Willgerodt Reaction
A novel solvent-free modification of the Willgerodt reaction is proposed. It employs elemental sulfur and ammonium salts as safe and convenient surrogates of ammonia on a solid carrier. The reaction involving a combination of ammonium carbonate and aluminum oxide afforded arylacetamides in 48 to 85% yields.
Authors
- Evgeniy A. Kvetkin (ORCID: https://orcid.org/0009-0009-1014-0297)
- Andrey V. Sokolov (ORCID: https://orcid.org/0000-0003-4965-3136)
Institutions
- Samara State Medical University (RU)
Publication Details
- Journal
- Russian Journal of Organic Chemistry
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1134/s1070428024603273
- Primary Topic
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00