Perflutren lipid microspheres for echocardiogram contrast: a clinical case of anaphylaxis not caused by PEG
Our case report highlights a previously undocumented instance of anaphylaxis to Definity® not caused by PEG. We suspect the reaction to be an IgE-mediated response to a non-PEGylated component of Definity®. An alternative explanation for the reaction could be a complement activation-related pseudoallergy. This report provides critical information to physicians on the potential risks of using Definity® and contributes to growing research surrounding the profile of Definity®.
Authors
- Erika Yue Lee (ORCID: https://orcid.org/0000-0003-1108-2067)
- Xiaoming Wang (ORCID: https://orcid.org/0000-0003-1232-3125)
- J. A. Campbell (ORCID: https://orcid.org/0000-0002-1456-7994)
- Harriet Lea-Banks
Institutions
- Western University (CA)
- Sunnybrook Health Science Centre (CA)
- University of Toronto (CA)
- Sunnybrook Research Institute
Publication Details
- Journal
- Allergy Asthma and Clinical Immunology
- Published
- 2025-05-07
- DOI
- https://doi.org/10.1186/s13223-025-00964-5
- Citations
- 1
- Primary Topic
- Food Allergy and Anaphylaxis Research
- Type
- article
- Field-Weighted Citation Impact
- 1.62