A Review: Study of Tulsi as Immune Booster

Tulsi (Ocimum sanctum), revered in Ayurveda as the "Queen of Herbs," has been extensively studied for its remarkable immunomodulatory properties, positioning it as a potent natural immune booster. This review consolidates contemporary scientific research and traditional wisdom to evaluate Tulsi’s multifaceted role in enhancing immune function. Rich in bioactive compounds such as eugenol, ursolic acid, rosmarinic acid, and β-caryophyllene, Tulsi exerts its immuneenhancing effects through antioxidant, anti-inflammatory, antimicrobial, and adaptogenic mechanisms. Preclinical and clinical studies demonstrate that Tulsi augments innate and adaptive immunity by modulating key immune cells, including macrophages, neutrophils, T-cells, and natural killer (NK) cells, while also enhancing antibody production. Its ability to mitigate oxidative stress and suppress pro-inflammatory cytokines (e.g., TNF-α, IL-6) further supports its role in maintaining immune homeostasis. Additionally, Tulsi’s adaptogenic properties help counteract stress-induced immunosuppression by regulating the hypothalamic-pituitary-adrenal (HPA) axis, thereby bolstering overall immune resilience. Emerging evidence suggests its efficacy against viral and bacterial infections, making it particularly relevant in the post-pandemic era. Despite promising findings, further well-designed clinical trials are needed to standardize dosage and optimize therapeutic protocols. This review underscores Tulsi’s potential as a safe, holistic, and evidence-based immune booster, bridging the gap between traditional medicine and modern scientific validation.