Characterization of the family-level <i>Borreliaceae</i> pan-genome and development of an episomal typing protocol
Using whole genome sequencing, we demonstrated that the bacteria that are transmitted by ticks and other arthropod vectors that cause Lyme disease and relapsing fevers, while related, do not belong within the same genus classification. In addition, through characterization of their highly atypical genomic structure, we were able to develop a genetic typing system that will help with future studies of how they cause disease while also providing targets for medical interventions.
Authors
- Richard T. Marconi (ORCID: https://orcid.org/0000-0002-6035-7306)
- Nicholas A. Cramer (ORCID: https://orcid.org/0000-0003-1237-4168)
- Bhaswati Sen
- Rachel L. Ehrlich
- Joshua Chang Mell (ORCID: https://orcid.org/0000-0003-0222-5636)
- Garth D. Ehrlich (ORCID: https://orcid.org/0000-0003-0341-8771)
- Kalya M. Socarras
- Azad Ahmed
- Mary C. Marino
- Joshua P. Earl (ORCID: https://orcid.org/0000-0002-9830-5173)
Institutions
- Center for Genomic Science (IT)
- Institute for Molecular Medicine (US)
- Virginia Commonwealth University Medical Center (US)
- Drexel University (US)
Publication Details
- Journal
- mBio
- Published
- 2025-05-07
- DOI
- https://doi.org/10.1128/mbio.00943-25
- Citations
- 2
- Primary Topic
- Vector-borne infectious diseases
- Type
- article
- Field-Weighted Citation Impact
- 4.10
Funders
- National Institute on Deafness and Other Communication Disorders
- National Institute of Allergy and Infectious Diseases
- National Institute of Diabetes and Digestive and Kidney Diseases